Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3775445..3776065 Replicon chromosome
Accession NZ_CP101647
Organism Salmonella enterica subsp. enterica serovar Kentucky strain KCID6

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NOQ94_RS18450 Protein ID WP_001280991.1
Coordinates 3775847..3776065 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag NOQ94_RS18445 Protein ID WP_000344807.1
Coordinates 3775445..3775819 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOQ94_RS18435 (3770583) 3770583..3771776 + 1194 WP_001039199.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NOQ94_RS18440 (3771799) 3771799..3774948 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
NOQ94_RS18445 (3775445) 3775445..3775819 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
NOQ94_RS18450 (3775847) 3775847..3776065 + 219 WP_001280991.1 HHA domain-containing protein Toxin
NOQ94_RS18455 (3776244) 3776244..3776795 + 552 WP_001278793.1 maltose O-acetyltransferase -
NOQ94_RS18460 (3776913) 3776913..3777383 + 471 WP_000136183.1 YlaC family protein -
NOQ94_RS18465 (3777439) 3777439..3777579 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
NOQ94_RS18470 (3777585) 3777585..3777845 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
NOQ94_RS18475 (3778070) 3778070..3779620 + 1551 WP_000213145.1 EAL domain-containing protein -
NOQ94_RS18485 (3779851) 3779851..3780240 + 390 WP_023224410.1 MGMT family protein -
NOQ94_RS18490 (3780273) 3780273..3780842 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T252424 WP_001280991.1 NZ_CP101647:3775847-3776065 [Salmonella enterica subsp. enterica serovar Kentucky]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT252424 WP_000344807.1 NZ_CP101647:3775445-3775819 [Salmonella enterica subsp. enterica serovar Kentucky]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References