252423

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2788895..2789417 Replicon chromosome
Accession NZ_CP101647
Organism Salmonella enterica subsp. enterica serovar Kentucky strain KCID6

Toxin (Protein)


Gene name stbE Uniprot ID V7IL40
Locus tag NOQ94_RS13570 Protein ID WP_000221345.1
Coordinates 2789133..2789417 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag NOQ94_RS13565 Protein ID WP_000885424.1
Coordinates 2788895..2789143 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOQ94_RS13535 (2784421) 2784421..2785329 - 909 WP_052939372.1 LysR family transcriptional regulator -
NOQ94_RS13540 (2785731) 2785731..2785919 + 189 WP_001276021.1 DUF29 family protein -
NOQ94_RS13545 (2786285) 2786285..2787024 + 740 Protein_2627 hypothetical protein -
NOQ94_RS13550 (2787026) 2787026..2787934 - 909 WP_077906523.1 hypothetical protein -
NOQ94_RS13555 (2788207) 2788207..2788538 - 332 Protein_2629 DUF1493 family protein -
NOQ94_RS13560 (2788624) 2788624..2788743 - 120 Protein_2630 type II and III secretion system -
NOQ94_RS13565 (2788895) 2788895..2789143 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NOQ94_RS13570 (2789133) 2789133..2789417 + 285 WP_000221345.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NOQ94_RS13575 (2789588) 2789588..2789977 + 390 WP_000194089.1 RidA family protein -
NOQ94_RS13580 (2790029) 2790029..2791108 - 1080 WP_023203126.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
NOQ94_RS13585 (2791301) 2791301..2791789 - 489 WP_023223899.1 MarR family winged helix-turn-helix transcriptional regulator -
NOQ94_RS13590 (2791834) 2791834..2792697 + 864 Protein_2636 FAD-dependent monooxygenase -
NOQ94_RS13595 (2792681) 2792681..2793247 + 567 Protein_2637 MFS transporter -
NOQ94_RS13600 (2793222) 2793222..2794247 + 1026 WP_000864928.1 zinc-binding alcohol dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2781549..2792748 11199


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11043.79 Da        Isoelectric Point: 10.6500

>T252423 WP_000221345.1 NZ_CP101647:2789133-2789417 [Salmonella enterica subsp. enterica serovar Kentucky]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT252423 WP_000885424.1 NZ_CP101647:2788895-2789143 [Salmonella enterica subsp. enterica serovar Kentucky]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Y2FFA8

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References