Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1394122..1394936 Replicon chromosome
Accession NZ_CP101647
Organism Salmonella enterica subsp. enterica serovar Kentucky strain KCID6

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A3G3DUX8
Locus tag NOQ94_RS06730 Protein ID WP_000971653.1
Coordinates 1394122..1394649 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag NOQ94_RS06735 Protein ID WP_000855694.1
Coordinates 1394646..1394936 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOQ94_RS06700 (1390496) 1390496..1390894 + 399 Protein_1292 cytoplasmic protein -
NOQ94_RS06705 (1391105) 1391105..1391323 + 219 Protein_1293 hypothetical protein -
NOQ94_RS06710 (1391480) 1391480..1392148 + 669 WP_000445914.1 hypothetical protein -
NOQ94_RS06715 (1392175) 1392175..1392669 + 495 WP_000424946.1 hypothetical protein -
NOQ94_RS06720 (1392841) 1392841..1393497 - 657 WP_023225036.1 protein-serine/threonine phosphatase -
NOQ94_RS06725 (1393847) 1393847..1394049 + 203 Protein_1297 IS5/IS1182 family transposase -
NOQ94_RS06730 (1394122) 1394122..1394649 - 528 WP_000971653.1 GNAT family N-acetyltransferase Toxin
NOQ94_RS06735 (1394646) 1394646..1394936 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
NOQ94_RS06740 (1395207) 1395207..1395407 - 201 Protein_1300 transposase -
NOQ94_RS06745 (1395648) 1395648..1395974 + 327 WP_000393295.1 hypothetical protein -
NOQ94_RS06750 (1396247) 1396247..1396595 - 349 Protein_1302 DUF1493 family protein -
NOQ94_RS06755 (1396580) 1396580..1397029 - 450 WP_023225038.1 hypothetical protein -
NOQ94_RS06760 (1397461) 1397461..1397904 - 444 WP_023225039.1 SPI-1 type III secretion system invasion lipoprotein InvH -
NOQ94_RS06765 (1398362) 1398362..1399012 + 651 WP_072203970.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - invH / invF / invG / invG / invE / invA / invB 1392841..1404326 11485
- inside IScluster/Tn - - 1393873..1395407 1534


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19043.87 Da        Isoelectric Point: 9.7032

>T252418 WP_000971653.1 NZ_CP101647:c1394649-1394122 [Salmonella enterica subsp. enterica serovar Kentucky]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRHDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT252418 WP_000855694.1 NZ_CP101647:c1394936-1394646 [Salmonella enterica subsp. enterica serovar Kentucky]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G3DUX8

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References