Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1225949..1226609 Replicon chromosome
Accession NZ_CP101647
Organism Salmonella enterica subsp. enterica serovar Kentucky strain KCID6

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag NOQ94_RS05960 Protein ID WP_000244756.1
Coordinates 1226196..1226609 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag NOQ94_RS05955 Protein ID WP_000351186.1
Coordinates 1225949..1226215 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOQ94_RS05935 (1221878) 1221878..1223311 - 1434 WP_001230143.1 6-phospho-beta-glucosidase BglA -
NOQ94_RS05940 (1223469) 1223469..1223780 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
NOQ94_RS05945 (1223944) 1223944..1224603 + 660 WP_000250289.1 hemolysin III family protein -
NOQ94_RS05950 (1224719) 1224719..1225699 - 981 WP_000874178.1 tRNA-modifying protein YgfZ -
NOQ94_RS05955 (1225949) 1225949..1226215 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
NOQ94_RS05960 (1226196) 1226196..1226609 + 414 WP_000244756.1 protein YgfX Toxin
NOQ94_RS05965 (1226662) 1226662..1227183 - 522 WP_001055885.1 flavodoxin FldB -
NOQ94_RS05970 (1227296) 1227296..1228192 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
NOQ94_RS05975 (1228216) 1228216..1228929 + 714 WP_023223829.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NOQ94_RS05980 (1228935) 1228935..1230668 + 1734 WP_023223830.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T252417 WP_000244756.1 NZ_CP101647:1226196-1226609 [Salmonella enterica subsp. enterica serovar Kentucky]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT252417 WP_000351186.1 NZ_CP101647:1225949-1226215 [Salmonella enterica subsp. enterica serovar Kentucky]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References