252407

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1221843..1222760 Replicon chromosome
Accession NZ_CP101621
Organism Bacillus velezensis strain 906

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A6A8LGT8
Locus tag NN913_RS06435 Protein ID WP_003154806.1
Coordinates 1222014..1222760 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID -
Locus tag NN913_RS06430 Protein ID WP_255764242.1
Coordinates 1221843..1222013 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NN913_RS06390 (NN913_06390) 1217065..1218696 + 1632 WP_255764241.1 pyocin knob domain-containing protein -
NN913_RS06395 (NN913_06395) 1218709..1219080 + 372 WP_014304856.1 XkdW family protein -
NN913_RS06400 (NN913_06400) 1219086..1219283 + 198 WP_003154819.1 XkdX family protein -
NN913_RS06405 (NN913_06405) 1219340..1220101 + 762 WP_063174221.1 hypothetical protein -
NN913_RS06410 (NN913_06410) 1220153..1220416 + 264 WP_003154815.1 hemolysin XhlA family protein -
NN913_RS06415 (NN913_06415) 1220430..1220693 + 264 WP_003154813.1 phage holin -
NN913_RS06420 (NN913_06420) 1220707..1221585 + 879 WP_024085195.1 N-acetylmuramoyl-L-alanine amidase -
NN913_RS06425 (NN913_06425) 1221621..1221746 - 126 WP_003154809.1 hypothetical protein -
NN913_RS06430 (NN913_06430) 1221843..1222013 - 171 WP_255764242.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
NN913_RS06435 (NN913_06435) 1222014..1222760 - 747 WP_003154806.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
NN913_RS06440 (NN913_06440) 1222865..1223863 - 999 WP_003154805.1 inorganic phosphate transporter -
NN913_RS06445 (NN913_06445) 1223876..1224493 - 618 WP_003154804.1 DUF47 domain-containing protein -
NN913_RS06450 (NN913_06450) 1224779..1226095 - 1317 WP_003154801.1 amino acid permease -
NN913_RS06455 (NN913_06455) 1226418..1227368 + 951 WP_255764243.1 ring-cleaving dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1187241..1250316 63075


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-239)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29034.50 Da        Isoelectric Point: 4.6947

>T252407 WP_003154806.1 NZ_CP101621:c1222760-1222014 [Bacillus velezensis]
MLLFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVVGAMVYWTYDPESLFAAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYGEKMNVTASL
CDYSAQSDKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQDRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6666.70 Da        Isoelectric Point: 10.9273

>AT252407 WP_255764242.1 NZ_CP101621:c1222013-1221843 [Bacillus velezensis]
MEQAFQNGQSEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6A8LGT8

Antitoxin

Source ID Structure

References