Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1345591..1346216 Replicon chromosome
Accession NZ_CP101615
Organism Escherichia coli strain DC71

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NOF56_RS06540 Protein ID WP_000911330.1
Coordinates 1345818..1346216 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag NOF56_RS06535 Protein ID WP_000450524.1
Coordinates 1345591..1345818 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOF56_RS06510 (1341394) 1341394..1341864 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
NOF56_RS06515 (1341864) 1341864..1342436 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
NOF56_RS06520 (1342582) 1342582..1343460 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
NOF56_RS06525 (1343477) 1343477..1344511 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
NOF56_RS06530 (1344724) 1344724..1345437 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
NOF56_RS06535 (1345591) 1345591..1345818 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
NOF56_RS06540 (1345818) 1345818..1346216 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
NOF56_RS06545 (1346363) 1346363..1347226 + 864 WP_001267507.1 neutral zinc metallopeptidase -
NOF56_RS06550 (1347241) 1347241..1349256 + 2016 WP_000829323.1 tRNA cytosine(34) acetyltransferase TmcA -
NOF56_RS06555 (1349330) 1349330..1349671 + 342 Protein_1280 esterase -
NOF56_RS06560 (1349753) 1349753..1350497 - 745 Protein_1281 IS21-like element ISEc12 family helper ATPase IstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T252387 WP_000911330.1 NZ_CP101615:1345818-1346216 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT252387 WP_000450524.1 NZ_CP101615:1345591-1345818 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References