252375

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 2280525..2281447 Replicon chromosome
Accession NZ_CP101610
Organism Bacillus siamensis strain WYJ-E14

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A120KSF0
Locus tag NNG64_RS10915 Protein ID WP_060962999.1
Coordinates 2280525..2281277 (+) Length 251 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID I2HQ14
Locus tag NNG64_RS10920 Protein ID WP_003154807.1
Coordinates 2281277..2281447 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NNG64_RS10895 (2275915) 2275915..2276865 - 951 WP_060962997.1 ring-cleaving dioxygenase -
NNG64_RS10900 (2277188) 2277188..2278504 + 1317 WP_060962998.1 amino acid permease -
NNG64_RS10905 (2278789) 2278789..2279406 + 618 WP_032874614.1 DUF47 domain-containing protein -
NNG64_RS10910 (2279419) 2279419..2280417 + 999 WP_044802872.1 inorganic phosphate transporter -
NNG64_RS10915 (2280525) 2280525..2281277 + 753 WP_060962999.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
NNG64_RS10920 (2281277) 2281277..2281447 + 171 WP_003154807.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
NNG64_RS10925 (2281544) 2281544..2281669 + 126 WP_141228459.1 hypothetical protein -
NNG64_RS10930 (2281706) 2281706..2282584 - 879 WP_060963000.1 N-acetylmuramoyl-L-alanine amidase -
NNG64_RS10935 (2282598) 2282598..2282861 - 264 WP_016936430.1 phage holin -
NNG64_RS10940 (2282875) 2282875..2283138 - 264 WP_003154815.1 hemolysin XhlA family protein -
NNG64_RS10945 (2283190) 2283190..2283990 - 801 WP_060965050.1 hypothetical protein -
NNG64_RS10950 (2284042) 2284042..2284206 - 165 WP_060963001.1 XkdX family protein -
NNG64_RS10955 (2284206) 2284206..2284538 - 333 WP_060963002.1 XkdW family protein -
NNG64_RS10960 (2284559) 2284559..2286292 - 1734 WP_060963003.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-239)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 251 a.a.        Molecular weight: 29357.82 Da        Isoelectric Point: 4.5756

>T252375 WP_060962999.1 NZ_CP101610:2280525-2281277 [Bacillus siamensis]
MLMFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVLGSMVYWTYDPESLFSAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYAEKMNVTASL
CDYSAQSDKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQDRHYVIKLTSETLLTEFDYLLFTSLTSIYDLML
PIEEEEEGDG

Download         Length: 753 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6676.74 Da        Isoelectric Point: 10.9273

>AT252375 WP_003154807.1 NZ_CP101610:2281277-2281447 [Bacillus siamensis]
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A120KSF0

Antitoxin

Source ID Structure
AlphaFold DB I2HQ14

References