Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 547697..548333 Replicon chromosome
Accession NZ_CP101609
Organism Bacillus altitudinis strain 47

Toxin (Protein)


Gene name mazF Uniprot ID K2MHT4
Locus tag NMH04_RS02620 Protein ID WP_003214169.1
Coordinates 547983..548333 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A267X601
Locus tag NMH04_RS02615 Protein ID WP_012008995.1
Coordinates 547697..547978 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMH04_RS02595 (NMH04_02590) 543851..544456 - 606 WP_007496491.1 rhomboid family intramembrane serine protease -
NMH04_RS02600 (NMH04_02595) 544551..544916 + 366 WP_255816870.1 holo-ACP synthase -
NMH04_RS02605 (NMH04_02600) 545077..546093 + 1017 WP_007496489.1 outer membrane lipoprotein-sorting protein -
NMH04_RS02610 (NMH04_02605) 546222..547403 + 1182 WP_255816871.1 alanine racemase -
NMH04_RS02615 (NMH04_02610) 547697..547978 + 282 WP_012008995.1 hypothetical protein Antitoxin
NMH04_RS02620 (NMH04_02615) 547983..548333 + 351 WP_003214169.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
NMH04_RS02625 (NMH04_02620) 548448..549278 + 831 WP_024719204.1 RsbT co-antagonist protein RsbRA -
NMH04_RS02630 (NMH04_02625) 549283..549651 + 369 WP_003214235.1 RsbT antagonist protein RsbS -
NMH04_RS02635 (NMH04_02630) 549654..550055 + 402 WP_003214085.1 anti-sigma regulatory factor -
NMH04_RS02640 (NMH04_02635) 550066..551073 + 1008 WP_061418047.1 PP2C family protein-serine/threonine phosphatase -
NMH04_RS02645 (NMH04_02640) 551133..551462 + 330 WP_113767289.1 anti-sigma factor antagonist -
NMH04_RS02650 (NMH04_02645) 551459..551947 + 489 WP_007496471.1 anti-sigma B factor RsbW -
NMH04_RS02655 (NMH04_02650) 551913..552701 + 789 WP_012009000.1 RNA polymerase sigma factor SigB -
NMH04_RS02660 (NMH04_02655) 552701..553300 + 600 WP_024719202.1 PP2C family serine/threonine-protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12976.99 Da        Isoelectric Point: 5.1663

>T252373 WP_003214169.1 NZ_CP101609:547983-548333 [Bacillus altitudinis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEINAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEALQVSLALIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10894.27 Da        Isoelectric Point: 5.2726

>AT252373 WP_012008995.1 NZ_CP101609:547697-547978 [Bacillus altitudinis]
MSESSATNEMKIRLPETLMSEIERVAEQDKVTRNELIYRATKTYIRERNIRQNRESMRRGYMEMAKINLNISSEAQYAEF
EAENTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K2MHT4

Antitoxin

Source ID Structure
AlphaFold DB A0A267X601

References