Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 14491..15134 Replicon plasmid pA84-2
Accession NZ_CP101597
Organism Cronobacter dublinensis strain CFSA A84

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag NNQ27_RS22640 Protein ID WP_275886476.1
Coordinates 14718..15134 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag NNQ27_RS22635 Protein ID WP_275886475.1
Coordinates 14491..14721 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NNQ27_RS22610 (NNQ27_22610) 9932..10891 - 960 WP_275886471.1 cupin domain-containing protein -
NNQ27_RS22615 (NNQ27_22615) 10891..12087 - 1197 WP_275886472.1 MFS transporter -
NNQ27_RS22620 (NNQ27_22620) 12089..12790 - 702 WP_275886473.1 class I SAM-dependent methyltransferase -
NNQ27_RS22625 (NNQ27_22625) 12793..13059 - 267 WP_076738041.1 PqqD family protein -
NNQ27_RS22630 (NNQ27_22630) 13421..13906 + 486 WP_275886474.1 GNAT family N-acetyltransferase -
NNQ27_RS22635 (NNQ27_22635) 14491..14721 + 231 WP_275886475.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NNQ27_RS22640 (NNQ27_22640) 14718..15134 + 417 WP_275886476.1 type II toxin-antitoxin system VapC family toxin Toxin
NNQ27_RS22645 (NNQ27_22645) 15176..16054 - 879 WP_275886477.1 restriction endonuclease -
NNQ27_RS22650 (NNQ27_22650) 16559..17725 + 1167 WP_275886478.1 hypothetical protein -
NNQ27_RS22655 (NNQ27_22655) 18256..19188 - 933 WP_275886479.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..38910 38910


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15103.54 Da        Isoelectric Point: 6.7053

>T252371 WP_275886476.1 NZ_CP101597:14718-15134 [Cronobacter dublinensis]
VNTTYMLDTCICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGLKASLRHVQLVEEFCARLDAVLPWDRA
AVDATTEIKVALRLAGTPIGANDTAIAGHAIAAGAVLVTNNVREFERVPGLVLEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8663.76 Da        Isoelectric Point: 4.3654

>AT252371 WP_275886475.1 NZ_CP101597:14491-14721 [Cronobacter dublinensis]
MRTVSIFKNGNNRAIRLPRDMDFEGVSELEIVREGDSIILRPVRPAWGSFAQLEKADPDFMAEREDVVSDEGRVDL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References