Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 146967..148570 Replicon plasmid pA84-1
Accession NZ_CP101596
Organism Cronobacter dublinensis strain CFSA A84

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NNQ27_RS22505 Protein ID WP_275886450.1
Coordinates 146967..148286 (-) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NNQ27_RS22510 Protein ID WP_038885763.1
Coordinates 148289..148570 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NNQ27_RS22495 (NNQ27_22495) 142349..144880 - 2532 WP_275886382.1 malto-oligosyltrehalose synthase -
NNQ27_RS22500 (NNQ27_22500) 144877..146661 - 1785 WP_275886383.1 malto-oligosyltrehalose trehalohydrolase -
NNQ27_RS22505 (NNQ27_22505) 146967..148286 - 1320 WP_275886450.1 type II toxin-antitoxin system HipA family toxin Toxin
NNQ27_RS22510 (NNQ27_22510) 148289..148570 - 282 WP_038885763.1 helix-turn-helix transcriptional regulator Antitoxin
NNQ27_RS22515 (NNQ27_22515) 148700..149587 - 888 WP_275886384.1 siderophore-interacting protein -
NNQ27_RS22520 (NNQ27_22520) 149584..150795 - 1212 WP_105679157.1 MFS transporter -
NNQ27_RS22525 (NNQ27_22525) 150931..152679 + 1749 WP_275886385.1 IucA/IucC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - mgtB / iucA / iucB / iucC / iutA 1..162169 162169


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(7-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-69)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49000.95 Da        Isoelectric Point: 7.5278

>T252370 WP_275886450.1 NZ_CP101596:c148286-146967 [Cronobacter dublinensis]
MRRTPRLALWMNGIPVGYWDKHNGEDRLTYLPEWTSDPQGRPLSLSLPFTPGNQPYRGARVRDYFDNLLPDSEGIRRRLA
TRYRAQSLAPFDLLAELGRDCVGAIQLLPDDETPEGLFTIRARLLSTVDIAAMLRHTAAPFAGQHGSDEELRLSIAGAQE
KTALLWHDGQWCLPEGNTPTTHIFKLPLGLVGNMQADMRTSIENEWLCSVLLEAYGVPVARTQMAQFGDQKALIVERFDR
RLSGDKQWWLRLPQEDMCQALGVSPLRKYQADGGPGIGDIMTILSRSEHAQADRAHFFRAQIIFWILAATDGHAKNFSIA
HLPGNRYHLTPLYDVLSAWPVIGPGNHQIAWQKCKLAMAVRGSSNYYHLSQIRRRHWLRQGELAGLSPAQVTEMIDELIA
ATPAAVARAAEALPAGFPSALADQIFDGMRQQCARLASA

Download         Length: 1320 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10419.87 Da        Isoelectric Point: 9.8278

>AT252370 WP_038885763.1 NZ_CP101596:c148570-148289 [Cronobacter dublinensis]
MNTVYPLKTLSQLRPLLVGFRKNQGLTQKEVSERLGVTQQTYARLEANPATASIERLFRVFNVLGIEMALSETQTLASDG
PARDDSPARREAW

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References