Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3639874..3640534 Replicon chromosome
Accession NZ_CP101595
Organism Cronobacter dublinensis strain CFSA A84

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag NNQ27_RS17540 Protein ID WP_275885082.1
Coordinates 3639874..3640287 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID K8AL19
Locus tag NNQ27_RS17545 Protein ID WP_007718966.1
Coordinates 3640268..3640534 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NNQ27_RS17520 (NNQ27_17520) 3635860..3637593 - 1734 WP_105633468.1 single-stranded-DNA-specific exonuclease RecJ -
NNQ27_RS17525 (NNQ27_17525) 3637597..3638316 - 720 WP_105647597.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NNQ27_RS17530 (NNQ27_17530) 3638339..3639235 - 897 WP_275885081.1 site-specific tyrosine recombinase XerD -
NNQ27_RS17535 (NNQ27_17535) 3639337..3639858 + 522 WP_007718971.1 flavodoxin FldB -
NNQ27_RS17540 (NNQ27_17540) 3639874..3640287 - 414 WP_275885082.1 protein YgfX Toxin
NNQ27_RS17545 (NNQ27_17545) 3640268..3640534 - 267 WP_007718966.1 FAD assembly factor SdhE Antitoxin
NNQ27_RS17550 (NNQ27_17550) 3640812..3641801 + 990 WP_275885083.1 tRNA-modifying protein YgfZ -
NNQ27_RS17555 (NNQ27_17555) 3641929..3642582 - 654 WP_275885084.1 hemolysin III family protein -
NNQ27_RS17560 (NNQ27_17560) 3642747..3643061 - 315 WP_161573301.1 N(4)-acetylcytidine aminohydrolase -
NNQ27_RS17565 (NNQ27_17565) 3643239..3643967 + 729 WP_275886327.1 MurR/RpiR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16375.39 Da        Isoelectric Point: 11.4887

>T252367 WP_275885082.1 NZ_CP101595:c3640287-3639874 [Cronobacter dublinensis]
VVLWHSDLRVSWRSQWVSLLLHGAVAVIILLLPWPLRYLPVWMLLLSLVVFDCVRSQRRINAFHGEVSLTADYQLRWQGV
DWEICATPWMLRSGMMLRLRHPKTTRSHHVWLASDSMMAKEWRDLRRLLLQQPVRDR

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10456.94 Da        Isoelectric Point: 5.1295

>AT252367 WP_007718966.1 NZ_CP101595:c3640534-3640268 [Cronobacter dublinensis]
MDINNKARIHWACRRGMRELDISIMPFFEHDYDSLSEEDKRVFVRLLECDDPDLFNWLMNHGKPADAELARMVQLIQQRN
QERGPVAL

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB K8AL19

References