Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 2836784..2837374 Replicon chromosome
Accession NZ_CP101595
Organism Cronobacter dublinensis strain CFSA A84

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag NNQ27_RS13750 Protein ID WP_105635764.1
Coordinates 2836784..2837116 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag NNQ27_RS13755 Protein ID WP_275884813.1
Coordinates 2837117..2837374 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NNQ27_RS13720 (NNQ27_13730) 2831879..2832784 + 906 WP_038870960.1 LysR family transcriptional regulator -
NNQ27_RS13725 (NNQ27_13735) 2832759..2834318 - 1560 WP_275884811.1 sensor domain-containing diguanylate cyclase -
NNQ27_RS13730 (NNQ27_13740) 2834611..2835330 - 720 WP_275884812.1 YnfC family lipoprotein -
NNQ27_RS13740 (NNQ27_13750) 2835755..2836552 + 798 WP_038870946.1 DgsA anti-repressor MtfA -
NNQ27_RS13750 (NNQ27_13760) 2836784..2837116 - 333 WP_105635764.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NNQ27_RS13755 (NNQ27_13765) 2837117..2837374 - 258 WP_275884813.1 antitoxin Antitoxin
NNQ27_RS13760 (NNQ27_13770) 2837906..2839225 + 1320 WP_275886312.1 shikimate transporter -
NNQ27_RS13765 (NNQ27_13775) 2839267..2840220 - 954 WP_007716325.1 HTH-type transcriptional regulator Cbl -
NNQ27_RS13770 (NNQ27_13780) 2840322..2841239 - 918 WP_038870936.1 nitrogen assimilation transcriptional regulator NAC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11935.71 Da        Isoelectric Point: 8.1080

>T252365 WP_105635764.1 NZ_CP101595:c2837116-2836784 [Cronobacter dublinensis]
MDRGEIWLVSLDPTAGHEQSGKRPVLIVSKASFNHVTRLPIVLPVTSGGNFARTAGFAVSLDGAGTKTTGVIRCDQPRTI
DMEARHGIRLERLPDHVVNEVLARLEAILN

Download         Length: 333 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9370.85 Da        Isoelectric Point: 4.4354

>AT252365 WP_275884813.1 NZ_CP101595:c2837374-2837117 [Cronobacter dublinensis]
MFTTRLKKVGGSIMLAVPPAVLKTLGLSTDSEVGMTIDNGCLIIEPQKRPRYSLDELLAQCDPHAEMSDEEREWIDTPAV
GKEIL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References