Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1165959..1166578 Replicon chromosome
Accession NZ_CP101595
Organism Cronobacter dublinensis strain CFSA A84

Toxin (Protein)


Gene name Hha Uniprot ID K8B192
Locus tag NNQ27_RS05595 Protein ID WP_007713751.1
Coordinates 1165959..1166177 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID K8AHS7
Locus tag NNQ27_RS05600 Protein ID WP_007713750.1
Coordinates 1166204..1166578 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NNQ27_RS05570 (NNQ27_05580) 1162081..1163982 + 1902 WP_007755675.1 methyl-accepting chemotaxis protein -
NNQ27_RS05575 (NNQ27_05585) 1164125..1164385 + 261 WP_007713755.1 type B 50S ribosomal protein L31 -
NNQ27_RS05580 (NNQ27_05590) 1164389..1164529 + 141 WP_275885827.1 type B 50S ribosomal protein L36 -
NNQ27_RS05585 (NNQ27_05595) 1164559..1165068 - 510 WP_007713753.1 YlaC family protein -
NNQ27_RS05590 (NNQ27_05600) 1165188..1165739 - 552 WP_038873740.1 maltose O-acetyltransferase -
NNQ27_RS05595 (NNQ27_05605) 1165959..1166177 - 219 WP_007713751.1 HHA domain-containing protein Toxin
NNQ27_RS05600 (NNQ27_05610) 1166204..1166578 - 375 WP_007713750.1 Hha toxicity modulator TomB Antitoxin
NNQ27_RS05605 (NNQ27_05615) 1167098..1170247 - 3150 WP_105630580.1 multidrug efflux RND transporter permease subunit AcrB -
NNQ27_RS05610 (NNQ27_05620) 1170269..1171471 - 1203 WP_032990671.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8624.06 Da        Isoelectric Point: 9.4828

>T252360 WP_007713751.1 NZ_CP101595:c1166177-1165959 [Cronobacter dublinensis]
MTTKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELPDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14417.15 Da        Isoelectric Point: 4.7269

>AT252360 WP_007713750.1 NZ_CP101595:c1166578-1166204 [Cronobacter dublinensis]
MDEYSPKRHDMAQLKFLCESLYHDCLATLGENQHGWVNDPTSAVNLQLNDLIEHIASFALNYKIKHEEDAALIEQLDEYL
DDTFMLFSNYGINAQDLQKWRKSGNRLFRCFVNASRENPVSLSF

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K8B192

Antitoxin

Source ID Structure
AlphaFold DB K8AHS7

References