Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 5029..5672 Replicon plasmid pA14-2
Accession NZ_CP101593
Organism Cronobacter dublinensis strain CFSA A14

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag NMY27_RS22185 Protein ID WP_275877183.1
Coordinates 5256..5672 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag NMY27_RS22180 Protein ID WP_275877182.1
Coordinates 5029..5259 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMY27_RS22150 (NMY27_22110) 234..1106 + 873 WP_023897702.1 RepB family plasmid replication initiator protein -
NMY27_RS22155 (NMY27_22115) 1275..1493 + 219 WP_012815882.1 hypothetical protein -
NMY27_RS22160 (NMY27_22120) 1486..2274 - 789 WP_032968471.1 site-specific integrase -
NMY27_RS22165 (NMY27_22125) 2264..3109 - 846 WP_275877180.1 hypothetical protein -
NMY27_RS22170 (NMY27_22130) 3351..4085 - 735 WP_275877181.1 hypothetical protein -
NMY27_RS22175 (NMY27_22135) 4155..4487 - 333 WP_032968469.1 hypothetical protein -
NMY27_RS22180 (NMY27_22140) 5029..5259 + 231 WP_275877182.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NMY27_RS22185 (NMY27_22145) 5256..5672 + 417 WP_275877183.1 type II toxin-antitoxin system VapC family toxin Toxin
NMY27_RS22190 (NMY27_22150) 5687..6445 + 759 WP_275877184.1 hypothetical protein -
NMY27_RS22195 (NMY27_22155) 7076..8242 + 1167 WP_275877185.1 hypothetical protein -
NMY27_RS22200 (NMY27_22160) 8426..10279 - 1854 WP_275877186.1 asparagine synthase (glutamine-hydrolyzing) -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..42474 42474


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-55)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15200.73 Da        Isoelectric Point: 8.7589

>T252358 WP_275877183.1 NZ_CP101593:5256-5672 [Cronobacter dublinensis]
MNKIYMLDTCICSFIMREQPEAVRKRLAQAVLRGHRIVISAITYSEMRFGATGPKASSRHIQLVNEFCTRLDAVLPWDRA
AVDATTEIKVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFERVPGLLLEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8933.02 Da        Isoelectric Point: 4.2188

>AT252358 WP_275877182.1 NZ_CP101593:5029-5259 [Cronobacter dublinensis]
MRTVSIFKNGNNRAIRLPRDMDFEGVSELEIIREGDSIILRPVRPTWDSFFELERADPDFMAEREDVVTDEGRFDL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References