252357

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 161239..162842 Replicon plasmid pA14-1
Accession NZ_CP101592
Organism Cronobacter dublinensis strain CFSA A14

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NMY27_RS22095 Protein ID WP_275877166.1
Coordinates 161239..162558 (-) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NMY27_RS22100 Protein ID WP_038885763.1
Coordinates 162561..162842 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMY27_RS22085 (NMY27_22045) 156621..159152 - 2532 WP_275877114.1 malto-oligosyltrehalose synthase -
NMY27_RS22090 (NMY27_22050) 159149..160933 - 1785 WP_275877115.1 malto-oligosyltrehalose trehalohydrolase -
NMY27_RS22095 (NMY27_22055) 161239..162558 - 1320 WP_275877166.1 type II toxin-antitoxin system HipA family toxin Toxin
NMY27_RS22100 (NMY27_22060) 162561..162842 - 282 WP_038885763.1 helix-turn-helix transcriptional regulator Antitoxin
NMY27_RS22105 (NMY27_22065) 162972..163859 - 888 WP_105694440.1 siderophore-interacting protein -
NMY27_RS22110 (NMY27_22070) 163856..165067 - 1212 WP_161573667.1 MFS transporter -
NMY27_RS22115 (NMY27_22075) 165203..166951 + 1749 WP_275877116.1 IucA/IucC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - mgtB / iucA / iucB / iucC / iutA 1..176445 176445


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(7-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-69)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 48882.86 Da        Isoelectric Point: 8.0243

>T252357 WP_275877166.1 NZ_CP101592:c162558-161239 [Cronobacter dublinensis]
MRRTPRLALWMNGIPVGYWDKHNGEDRLTYLPEWTSDPQGRPLSLSLPFTPGNQPYRGARVRDYFDNLLPDSEGIRRRLA
TRYRAQSLAPFDLLAELGRDCVGAIQLLPDGETPEGLFTIRARPLSTVDIAAMLRHTAAPFAGQHGSDEELRLSIAGAQE
KTALLWHDGQWCLPEGNTPTTHIFKLPLGLVGNMQADMRTSIENEWLCSVLLEAYGIPVARTQMAQFGDQKALIVERFDR
RLSGDKQWWLRLPQEDMCQALGVSPLRKYQADGGPGIGDIMTILSRSEHAQADRAHFFRAQIIFWILAATDGHAKNFSIA
HLPGNRYHLTPLYDVLSAWPVIGPGNHQIAWQKCKLAMAVRGSSNYYHLSQIRRRHWLRQGELAGLSPAQVTEMIDELIA
ATPAAVARAAEALPAGFPSALAGQIFDGMRQQCARLASA

Download         Length: 1320 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10419.87 Da        Isoelectric Point: 9.8278

>AT252357 WP_038885763.1 NZ_CP101592:c162842-162561 [Cronobacter dublinensis]
MNTVYPLKTLSQLRPLLVGFRKNQGLTQKEVSERLGVTQQTYARLEANPATASIERLFRVFNVLGIEMALSETQTLASDG
PARDDSPARREAW

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References