Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3575696..3576356 Replicon chromosome
Accession NZ_CP101591
Organism Cronobacter dublinensis strain CFSA A14

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag NMY27_RS17150 Protein ID WP_038869689.1
Coordinates 3575696..3576109 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID K8AL19
Locus tag NMY27_RS17155 Protein ID WP_007718966.1
Coordinates 3576090..3576356 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMY27_RS17130 (NMY27_17110) 3571682..3573415 - 1734 WP_105633468.1 single-stranded-DNA-specific exonuclease RecJ -
NMY27_RS17135 (NMY27_17115) 3573419..3574138 - 720 WP_007752085.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NMY27_RS17140 (NMY27_17120) 3574161..3575057 - 897 WP_105640099.1 site-specific tyrosine recombinase XerD -
NMY27_RS17145 (NMY27_17125) 3575159..3575680 + 522 WP_007718971.1 flavodoxin FldB -
NMY27_RS17150 (NMY27_17130) 3575696..3576109 - 414 WP_038869689.1 protein YgfX Toxin
NMY27_RS17155 (NMY27_17135) 3576090..3576356 - 267 WP_007718966.1 FAD assembly factor SdhE Antitoxin
NMY27_RS17160 (NMY27_17140) 3576634..3577623 + 990 WP_275876027.1 tRNA-modifying protein YgfZ -
NMY27_RS17165 (NMY27_17145) 3577753..3578406 - 654 WP_105633465.1 hemolysin III family protein -
NMY27_RS17170 (NMY27_17150) 3578569..3578883 - 315 WP_275876028.1 N(4)-acetylcytidine aminohydrolase -
NMY27_RS17175 (NMY27_17155) 3579061..3579789 + 729 WP_275877059.1 MurR/RpiR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16259.21 Da        Isoelectric Point: 11.5129

>T252354 WP_038869689.1 NZ_CP101591:c3576109-3575696 [Cronobacter dublinensis]
VVLWHSDLRVSWRSQWVSLLLHGAVAVIILLLPWPLRYLPVWMLLLSLVVFDCVRSQRRINAFHGEVSLTADYQLRWQGV
DWEICATPWMLRSGMMLRLRHPKTTRSHHVWLASDSMTAKEWRDLRRLLLQQPVQGR

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10456.94 Da        Isoelectric Point: 5.1295

>AT252354 WP_007718966.1 NZ_CP101591:c3576356-3576090 [Cronobacter dublinensis]
MDINNKARIHWACRRGMRELDISIMPFFEHDYDSLSEEDKRVFVRLLECDDPDLFNWLMNHGKPADAELARMVQLIQQRN
QERGPVAL

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB K8AL19

References