Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 2758320..2758910 Replicon chromosome
Accession NZ_CP101591
Organism Cronobacter dublinensis strain CFSA A14

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag NMY27_RS13270 Protein ID WP_161590144.1
Coordinates 2758320..2758652 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag NMY27_RS13275 Protein ID WP_007749978.1
Coordinates 2758653..2758910 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMY27_RS13240 (NMY27_13230) 2753413..2754318 + 906 WP_275875780.1 LysR family transcriptional regulator -
NMY27_RS13245 (NMY27_13235) 2754293..2755852 - 1560 WP_275875781.1 sensor domain-containing diguanylate cyclase -
NMY27_RS13250 (NMY27_13240) 2756146..2756865 - 720 WP_275875782.1 YnfC family lipoprotein -
NMY27_RS13260 (NMY27_13250) 2757291..2758088 + 798 WP_275875783.1 DgsA anti-repressor MtfA -
NMY27_RS13270 (NMY27_13260) 2758320..2758652 - 333 WP_161590144.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NMY27_RS13275 (NMY27_13265) 2758653..2758910 - 258 WP_007749978.1 programmed cell death antitoxin PemI Antitoxin
NMY27_RS13280 (NMY27_13270) 2759441..2760760 + 1320 WP_275877047.1 shikimate transporter -
NMY27_RS13285 (NMY27_13275) 2760802..2761755 - 954 WP_007716325.1 HTH-type transcriptional regulator Cbl -
NMY27_RS13290 (NMY27_13280) 2761857..2762774 - 918 WP_038870936.1 nitrogen assimilation transcriptional regulator NAC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11949.74 Da        Isoelectric Point: 8.1081

>T252352 WP_161590144.1 NZ_CP101591:c2758652-2758320 [Cronobacter dublinensis]
MDRGEIWLVSLDPTAGHEQSGKRPVLIVSKASFNHVTRLPIVLPVTSGGNFARTAGFAVSLEGAGTKTTGVIRCDQPRTI
DMEARHGIRLERLPDHVVNEVLARLEAILN

Download         Length: 333 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9356.83 Da        Isoelectric Point: 4.4217

>AT252352 WP_007749978.1 NZ_CP101591:c2758910-2758653 [Cronobacter dublinensis]
MFTTRLKKVGGSIMLAVPPAVLKTLGLSTDSEVGMTIDNGCLIIEPQKRPRYSLDELLAQCDPHAEMSDEDREWIDTPAV
GKEIL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References