Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1153181..1153800 Replicon chromosome
Accession NZ_CP101591
Organism Cronobacter dublinensis strain CFSA A14

Toxin (Protein)


Gene name Hha Uniprot ID V5U1U2
Locus tag NMY27_RS05530 Protein ID WP_007781479.1
Coordinates 1153181..1153399 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID K8AHS7
Locus tag NMY27_RS05535 Protein ID WP_007713750.1
Coordinates 1153426..1153800 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMY27_RS05505 (NMY27_05500) 1149299..1151200 + 1902 WP_007755675.1 methyl-accepting chemotaxis protein -
NMY27_RS05510 (NMY27_05505) 1151344..1151604 + 261 WP_007713755.1 type B 50S ribosomal protein L31 -
NMY27_RS05515 (NMY27_05510) 1151608..1151748 + 141 WP_007713754.1 type B 50S ribosomal protein L36 -
NMY27_RS05520 (NMY27_05515) 1151778..1152287 - 510 WP_007713753.1 YlaC family protein -
NMY27_RS05525 (NMY27_05520) 1152407..1152958 - 552 WP_038873740.1 maltose O-acetyltransferase -
NMY27_RS05530 (NMY27_05525) 1153181..1153399 - 219 WP_007781479.1 HHA domain-containing protein Toxin
NMY27_RS05535 (NMY27_05530) 1153426..1153800 - 375 WP_007713750.1 Hha toxicity modulator TomB Antitoxin
NMY27_RS05540 (NMY27_05535) 1154321..1157470 - 3150 WP_007755683.1 multidrug efflux RND transporter permease subunit AcrB -
NMY27_RS05545 (NMY27_05540) 1157492..1158694 - 1203 WP_007713748.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8614.02 Da        Isoelectric Point: 9.4828

>T252347 WP_007781479.1 NZ_CP101591:c1153399-1153181 [Cronobacter dublinensis]
MTTKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14417.15 Da        Isoelectric Point: 4.7269

>AT252347 WP_007713750.1 NZ_CP101591:c1153800-1153426 [Cronobacter dublinensis]
MDEYSPKRHDMAQLKFLCESLYHDCLATLGENQHGWVNDPTSAVNLQLNDLIEHIASFALNYKIKHEEDAALIEQLDEYL
DDTFMLFSNYGINAQDLQKWRKSGNRLFRCFVNASRENPVSLSF

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V5U1U2

Antitoxin

Source ID Structure
AlphaFold DB K8AHS7

References