Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 240317..241200 Replicon chromosome
Accession NZ_CP101591
Organism Cronobacter dublinensis strain CFSA A14

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag NMY27_RS01305 Protein ID WP_105648060.1
Coordinates 240673..241200 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID -
Locus tag NMY27_RS01300 Protein ID WP_275876401.1
Coordinates 240317..240676 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMY27_RS01280 (NMY27_01280) 235478..236155 + 678 WP_038886062.1 6-hydroxyaminopurine reductase -
NMY27_RS01285 (NMY27_01285) 236325..237530 - 1206 WP_275876400.1 FMN-dependent L-lactate dehydrogenase LldD -
NMY27_RS01290 (NMY27_01290) 237530..238315 - 786 WP_038875512.1 transcriptional regulator LldR -
NMY27_RS01295 (NMY27_01295) 238312..239967 - 1656 WP_105685872.1 L-lactate permease -
NMY27_RS01300 (NMY27_01300) 240317..240676 + 360 WP_275876401.1 DUF1778 domain-containing protein Antitoxin
NMY27_RS01305 (NMY27_01305) 240673..241200 + 528 WP_105648060.1 GNAT family N-acetyltransferase Toxin
NMY27_RS01310 (NMY27_01310) 241240..241602 - 363 WP_007729196.1 YibL family ribosome-associated protein -
NMY27_RS01315 (NMY27_01315) 241733..243247 - 1515 WP_032967552.1 glycerol kinase GlpK -
NMY27_RS01320 (NMY27_01320) 243269..244117 - 849 WP_007729203.1 MIP/aquaporin family protein -
NMY27_RS01325 (NMY27_01325) 244552..244791 + 240 WP_007667757.1 septal ring assembly protein ZapB -
NMY27_RS01330 (NMY27_01330) 244841..245326 - 486 WP_007729210.1 ribonuclease E activity regulator RraA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-148)

Antitoxin

Vibrio phage ICP1, Orf50

(30-111)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19434.16 Da        Isoelectric Point: 9.0259

>T252346 WP_105648060.1 NZ_CP101591:240673-241200 [Cronobacter dublinensis]
MTLKRGVFSYAPEHGWKTASFDCGCDTLNDFLRQRLAVQQQRNVLRAYVVLTNEPEPAVAGYYTLSGASFERSLFGDRKR
QIPYDSAPCVLLGRLAVDKTHAGKGIGSMLVADAARRVYDVARAVGVYAMFVEAKDAHAAQFYQQLGFLQAESTDGRQRL
FFPIRALDALFTTTP

Download         Length: 528 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13352.07 Da        Isoelectric Point: 6.4845

>AT252346 WP_275876401.1 NZ_CP101591:240317-240676 [Cronobacter dublinensis]
MEPSAPTLHVRLFTVQQNRFLSGDSVMPAPSKKDRLECRLSTEDKAAIEAAASLSNTSVSQFIVDAARARARVLLEEHHR
IRLTEQGWHAVMAALDNPPAPNERLKRAFESLDNGEFWE

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References