Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 1396..1870 Replicon plasmid p29_4
Accession NZ_CP101571
Organism Klebsiella pneumoniae subsp. pneumoniae strain KP29

Toxin (Protein)


Gene name pasB Uniprot ID A0A8J3DT22
Locus tag NMY30_RS29280 Protein ID WP_004197762.1
Coordinates 1604..1870 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID S1EJF5
Locus tag NMY30_RS29275 Protein ID WP_000879771.1
Coordinates 1396..1620 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMY30_RS29260 (NMY30_29240) 1..510 + 510 WP_032433972.1 MbeB family mobilization protein -
NMY30_RS29265 (NMY30_29245) 517..729 + 213 WP_021527181.1 MbeD family mobilization/exclusion protein -
NMY30_RS29270 1105..1233 - 129 WP_000523570.1 hypothetical protein -
NMY30_RS29275 (NMY30_29250) 1396..1620 + 225 WP_000879771.1 DUF6290 family protein Antitoxin
NMY30_RS29280 (NMY30_29255) 1604..1870 + 267 WP_004197762.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NMY30_RS29285 (NMY30_29260) 1940..2290 - 351 WP_004197756.1 hypothetical protein -
NMY30_RS29290 (NMY30_29265) 2356..2901 - 546 WP_023317533.1 hypothetical protein -
NMY30_RS29295 (NMY30_29270) 2927..3253 - 327 WP_050516389.1 hypothetical protein -
NMY30_RS29300 (NMY30_29275) 4409..4585 + 177 WP_004197757.1 hypothetical protein -
NMY30_RS29305 (NMY30_29280) 4575..4919 + 345 WP_062955149.1 MobC family plasmid mobilization relaxosome protein -
NMY30_RS29310 (NMY30_29285) 5101..5346 - 246 WP_032433971.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..5596 5596


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Relaxosome protein TraY

(4-45)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10342.96 Da        Isoelectric Point: 9.8727

>T252345 WP_004197762.1 NZ_CP101571:1604-1870 [Klebsiella pneumoniae subsp. pneumoniae]
MVWTINYSDRALKSLRKMDKQNARRIVDFMSLRIAVAADPRQSGKPLKGELGEFWRYRVGDYRVLCEIRDDELVILAATI
GHRREVYD

Download         Length: 267 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8369.28 Da        Isoelectric Point: 4.6533

>AT252345 WP_000879771.1 NZ_CP101571:1396-1620 [Klebsiella pneumoniae subsp. pneumoniae]
MLAIRLSDEIESRLDSLAKQTGRTKTFYAREAILAHLEDLEDYYLSAETAARVRRGDEAVHSSEDVRKSLGLDD

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB S1EJF5

References