Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 1..581 Replicon plasmid p29_3
Accession NZ_CP101570
Organism Klebsiella pneumoniae subsp. pneumoniae strain KP29

Toxin (Protein)


Gene name parE Uniprot ID A0A8J3DTL7
Locus tag NMY30_RS29200 Protein ID WP_071177730.1
Coordinates 267..581 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2X1PRM1
Locus tag NMY30_RS29195 Protein ID WP_000093040.1
Coordinates 1..279 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMY30_RS29195 (NMY30_29175) 1..279 + 279 WP_000093040.1 CopG family ribbon-helix-helix protein Antitoxin
NMY30_RS29200 (NMY30_29180) 267..581 + 315 WP_071177730.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NMY30_RS29205 (NMY30_29185) 745..1173 + 429 WP_001140599.1 hypothetical protein -
NMY30_RS29210 (NMY30_29190) 1199..1378 + 180 WP_000165970.1 Rop family plasmid primer RNA-binding protein -
NMY30_RS29215 (NMY30_29195) 1405..1935 - 531 WP_071177729.1 hypothetical protein -
NMY30_RS29220 (NMY30_29200) 1942..2673 - 732 WP_071177728.1 MobC family replication-relaxation protein -
NMY30_RS29225 (NMY30_29205) 2673..4637 - 1965 WP_071177727.1 TraM recognition domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..10060 10060


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-96)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11805.73 Da        Isoelectric Point: 9.8324

>T252344 WP_071177730.1 NZ_CP101570:267-581 [Klebsiella pneumoniae subsp. pneumoniae]
MPQVTISALAQRDLQRLQDFLKTKNRLAARKGGEVIVRAIQQLKTLPDIGRPVPFLPLEYKELVIGFGDSGYVMLYRHDR
EMDQIVIVTVRHQKESGYPGADSL

Download         Length: 315 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10709.73 Da        Isoelectric Point: 4.7561

>AT252344 WP_000093040.1 NZ_CP101570:1-279 [Klebsiella pneumoniae subsp. pneumoniae]
MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEKRSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWG
TENEQDAPPCHR

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2X1PRM1

References