Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vagCD/VapC-VagC |
Location | 24649..25292 | Replicon | plasmid p29_2 |
Accession | NZ_CP101569 | ||
Organism | Klebsiella pneumoniae subsp. pneumoniae strain KP29 |
Toxin (Protein)
Gene name | vagD | Uniprot ID | D8L2J9 |
Locus tag | NMY30_RS28425 | Protein ID | WP_001044770.1 |
Coordinates | 24876..25292 (+) | Length | 139 a.a. |
Antitoxin (Protein)
Gene name | vagC | Uniprot ID | D5KTK7 |
Locus tag | NMY30_RS28420 | Protein ID | WP_001261282.1 |
Coordinates | 24649..24879 (+) | Length | 77 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
NMY30_RS28385 (19872) | 19872..20651 | - | 780 | WP_013214009.1 | site-specific integrase | - |
NMY30_RS28390 (20835) | 20835..21839 | - | 1005 | WP_011977814.1 | hypothetical protein | - |
NMY30_RS28395 (21869) | 21869..22072 | - | 204 | WP_011977813.1 | hypothetical protein | - |
NMY30_RS28400 (22118) | 22118..22639 | - | 522 | WP_013214008.1 | hypothetical protein | - |
NMY30_RS28405 (22697) | 22697..23089 | - | 393 | WP_011977811.1 | hypothetical protein | - |
NMY30_RS28410 (23126) | 23126..24070 | - | 945 | WP_011977810.1 | hypothetical protein | - |
NMY30_RS28415 (24231) | 24231..24692 | - | 462 | WP_014343465.1 | hypothetical protein | - |
NMY30_RS28420 (24649) | 24649..24879 | + | 231 | WP_001261282.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
NMY30_RS28425 (24876) | 24876..25292 | + | 417 | WP_001044770.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
NMY30_RS28430 (25366) | 25366..26544 | + | 1179 | Protein_34 | AAA family ATPase | - |
NMY30_RS28435 (26594) | 26594..27298 | - | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
NMY30_RS28440 (27359) | 27359..29934 | + | 2576 | Protein_36 | Tn3-like element TnAs1 family transposase | - |
NMY30_RS28445 (29971) | 29971..30039 | - | 69 | Protein_37 | IS6 family transposase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | blaSHV-12 / blaKPC-2 / rmtB / fosA3 / blaCTX-M-65 / catA2 | - | 1..138059 | 138059 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 15106.52 Da Isoelectric Point: 7.1084
>T252336 WP_001044770.1 NZ_CP101569:24876-25292 [Klebsiella pneumoniae subsp. pneumoniae]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGQRIVVSAITYSEMRFGATGPKASPRHVELVDAFCARLDAILPWDRA
AVDATTEIKVALRMAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVR
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGQRIVVSAITYSEMRFGATGPKASPRHVELVDAFCARLDAILPWDRA
AVDATTEIKVALRMAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVR
Download Length: 417 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GYM2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GZG3 |