Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 5039213..5040894 Replicon chromosome
Accession NZ_CP101563
Organism Klebsiella pneumoniae subsp. pneumoniae strain KP65

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag NMY31_RS24945 Protein ID WP_002885155.1
Coordinates 5039213..5040130 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID W8UPQ8
Locus tag NMY31_RS24950 Protein ID WP_004151732.1
Coordinates 5040136..5040894 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMY31_RS24925 (NMY31_24905) 5034519..5036039 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
NMY31_RS24930 (NMY31_24910) 5036036..5037034 + 999 WP_002885172.1 ribose ABC transporter permease -
NMY31_RS24935 (NMY31_24915) 5037065..5038006 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
NMY31_RS24940 (NMY31_24920) 5038081..5039088 + 1008 WP_004151731.1 carbohydrate kinase family protein -
NMY31_RS24945 (NMY31_24925) 5039213..5040130 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
NMY31_RS24950 (NMY31_24930) 5040136..5040894 - 759 WP_004151732.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
NMY31_RS24955 (NMY31_24935) 5040980..5041708 - 729 WP_002885152.1 response regulator transcription factor -
NMY31_RS24960 (NMY31_24940) 5041981..5044128 + 2148 WP_077598858.1 formate dehydrogenase subunit alpha -
NMY31_RS24965 (NMY31_24945) 5044358..5045044 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(95-246)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T252311 WP_002885155.1 NZ_CP101563:c5040130-5039213 [Klebsiella pneumoniae subsp. pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28564.92 Da        Isoelectric Point: 10.0870

>AT252311 WP_004151732.1 NZ_CP101563:c5040894-5040136 [Klebsiella pneumoniae subsp. pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GQB5

References