Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4834960..4835770 Replicon chromosome
Accession NZ_CP101554
Organism Klebsiella pneumoniae subsp. pneumoniae strain KP72

Toxin (Protein)


Gene name KacT Uniprot ID A0A0H3GMP0
Locus tag NMY33_RS23985 Protein ID WP_002887280.1
Coordinates 4834960..4835493 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag NMY33_RS23990 Protein ID WP_002887278.1
Coordinates 4835504..4835770 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMY33_RS23980 (NMY33_23970) 4833791..4834912 + 1122 WP_009309849.1 cupin domain-containing protein -
NMY33_RS23985 (NMY33_23975) 4834960..4835493 - 534 WP_002887280.1 type II toxin-antitoxin system toxin KacT Toxin
NMY33_RS23990 (NMY33_23980) 4835504..4835770 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
NMY33_RS23995 (NMY33_23985) 4835873..4837306 - 1434 WP_019724905.1 Cu(+)/Ag(+) sensor histidine kinase -
NMY33_RS24000 (NMY33_23990) 4837296..4837979 - 684 WP_004214143.1 copper response regulator transcription factor CusR -
NMY33_RS24005 (NMY33_23995) 4838151..4839533 + 1383 WP_019724904.1 efflux transporter outer membrane subunit -
NMY33_RS24010 (NMY33_24000) 4839551..4839895 + 345 WP_025987660.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19838.70 Da        Isoelectric Point: 5.2614

>T252287 WP_002887280.1 NZ_CP101554:c4835493-4834960 [Klebsiella pneumoniae subsp. pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHVMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT252287 WP_002887278.1 NZ_CP101554:c4835770-4835504 [Klebsiella pneumoniae subsp. pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5ZGN
PDB 5XUN

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References