Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2827219..2828807 Replicon chromosome
Accession NZ_CP101554
Organism Klebsiella pneumoniae subsp. pneumoniae strain KP72

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag NMY33_RS14005 Protein ID WP_004199851.1
Coordinates 2827219..2828541 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag NMY33_RS14010 Protein ID WP_002904790.1
Coordinates 2828541..2828807 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMY33_RS13990 (NMY33_13980) 2822284..2824785 + 2502 WP_004199853.1 fimbria/pilus outer membrane usher protein -
NMY33_RS13995 (NMY33_13985) 2824773..2825777 + 1005 WP_004199852.1 fimbrial protein -
NMY33_RS14000 (NMY33_13990) 2825910..2827202 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
NMY33_RS14005 (NMY33_13995) 2827219..2828541 - 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
NMY33_RS14010 (NMY33_14000) 2828541..2828807 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NMY33_RS14015 (NMY33_14005) 2829073..2829399 - 327 WP_002904788.1 hydroxyisourate hydrolase -
NMY33_RS14020 (NMY33_14010) 2829396..2829896 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NMY33_RS14025 (NMY33_14015) 2829874..2831253 - 1380 WP_004199850.1 nucleobase:cation symporter-2 family protein -
NMY33_RS14030 (NMY33_14020) 2831599..2832753 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
NMY33_RS14035 (NMY33_14025) 2832734..2833657 - 924 WP_004199849.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T252285 WP_004199851.1 NZ_CP101554:c2828541-2827219 [Klebsiella pneumoniae subsp. pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT252285 WP_002904790.1 NZ_CP101554:c2828807-2828541 [Klebsiella pneumoniae subsp. pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References