Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 710129..710970 Replicon chromosome
Accession NZ_CP101554
Organism Klebsiella pneumoniae subsp. pneumoniae strain KP72

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1M0WJM1
Locus tag NMY33_RS03535 Protein ID WP_000854822.1
Coordinates 710587..710970 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1M0CWL2
Locus tag NMY33_RS03530 Protein ID WP_053271974.1
Coordinates 710129..710497 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMY33_RS03510 (NMY33_03510) 707874..708692 + 819 WP_001234702.1 DUF932 domain-containing protein -
NMY33_RS03515 (NMY33_03515) 708783..709268 + 486 WP_000214317.1 antirestriction protein -
NMY33_RS03520 (NMY33_03520) 709283..709759 + 477 WP_001186747.1 RadC family protein -
NMY33_RS03525 (NMY33_03525) 709828..710049 + 222 WP_000692312.1 DUF987 domain-containing protein -
NMY33_RS03530 (NMY33_03530) 710129..710497 + 369 WP_053271974.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NMY33_RS03535 (NMY33_03535) 710587..710970 + 384 WP_000854822.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
NMY33_RS03540 (NMY33_03540) 710961..711449 + 489 WP_001177592.1 DUF5983 family protein -
NMY33_RS03545 (NMY33_03545) 711416..711658 + 243 WP_166635458.1 DUF957 domain-containing protein -
NMY33_RS03550 (NMY33_03550) 711755..712600 + 846 WP_001280435.1 DUF4942 domain-containing protein -
NMY33_RS03560 (NMY33_03560) 712899..713405 + 507 WP_002917636.1 G/U mismatch-specific DNA glycosylase -
NMY33_RS03565 (NMY33_03565) 713505..715346 - 1842 WP_004174339.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14295.32 Da        Isoelectric Point: 8.2830

>T252278 WP_000854822.1 NZ_CP101554:710587-710970 [Klebsiella pneumoniae subsp. pneumoniae]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHQESKRCN

Download         Length: 384 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13679.41 Da        Isoelectric Point: 6.4758

>AT252278 WP_053271974.1 NZ_CP101554:710129-710497 [Klebsiella pneumoniae subsp. pneumoniae]
VSDTFSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLTDRAGIRGRFSDADANHLDQAFPLLMKQLELMLTSS
ELNPHRQNTVTLYVKGLTCHADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M0WJM1

Antitoxin

Source ID Structure
AlphaFold DB A0A1M0CWL2

References