Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4848349..4850030 Replicon chromosome
Accession NZ_CP101546
Organism Klebsiella pneumoniae subsp. pneumoniae strain KP82

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag NMY34_RS24035 Protein ID WP_002885155.1
Coordinates 4848349..4849266 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID W8UPQ8
Locus tag NMY34_RS24040 Protein ID WP_004151732.1
Coordinates 4849272..4850030 (-) Length 253 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMY34_RS24015 (NMY34_24000) 4843655..4845175 + 1521 WP_220231920.1 sugar ABC transporter ATP-binding protein -
NMY34_RS24020 (NMY34_24005) 4845172..4846170 + 999 WP_002885172.1 ribose ABC transporter permease -
NMY34_RS24025 (NMY34_24010) 4846201..4847142 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
NMY34_RS24030 (NMY34_24015) 4847217..4848224 + 1008 WP_004151731.1 carbohydrate kinase family protein -
NMY34_RS24035 (NMY34_24020) 4848349..4849266 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
NMY34_RS24040 (NMY34_24025) 4849272..4850030 - 759 WP_004151732.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
NMY34_RS24045 (NMY34_24030) 4850116..4850844 - 729 WP_002885152.1 response regulator transcription factor -
NMY34_RS24050 (NMY34_24035) 4851117..4853264 + 2148 WP_077598858.1 formate dehydrogenase subunit alpha -
NMY34_RS24055 (NMY34_24040) 4853494..4854180 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T252272 WP_002885155.1 NZ_CP101546:c4849266-4848349 [Klebsiella pneumoniae subsp. pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp


Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28564.92 Da        Isoelectric Point: 10.0870

>AT252272 WP_004151732.1 NZ_CP101546:c4850030-4849272 [Klebsiella pneumoniae subsp. pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11


Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GQB5

References