Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4692165..4692681 Replicon chromosome
Accession NZ_CP101546
Organism Klebsiella pneumoniae subsp. pneumoniae strain KP82

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag NMY34_RS23235 Protein ID WP_002886902.1
Coordinates 4692165..4692449 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag NMY34_RS23240 Protein ID WP_002886901.1
Coordinates 4692439..4692681 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMY34_RS23210 (NMY34_23195) 4687649..4687912 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
NMY34_RS23215 (NMY34_23200) 4688042..4688215 + 174 WP_002886906.1 hypothetical protein -
NMY34_RS23220 (NMY34_23205) 4688218..4688961 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
NMY34_RS23225 (NMY34_23210) 4689318..4691456 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
NMY34_RS23230 (NMY34_23215) 4691697..4692161 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NMY34_RS23235 (NMY34_23220) 4692165..4692449 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NMY34_RS23240 (NMY34_23225) 4692439..4692681 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NMY34_RS23245 (NMY34_23230) 4692759..4694669 - 1911 WP_004152270.1 PRD domain-containing protein -
NMY34_RS23250 (NMY34_23235) 4694692..4695846 - 1155 WP_002886900.1 lactonase family protein -
NMY34_RS23255 (NMY34_23240) 4695912..4696652 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T252271 WP_002886902.1 NZ_CP101546:c4692449-4692165 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT252271 WP_002886901.1 NZ_CP101546:c4692681-4692439 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References