Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 836265..836922 Replicon chromosome
Accession NZ_CP101546
Organism Klebsiella pneumoniae subsp. pneumoniae strain KP82

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag NMY34_RS04230 Protein ID WP_002916310.1
Coordinates 836512..836922 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag NMY34_RS04225 Protein ID WP_002916312.1
Coordinates 836265..836531 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMY34_RS04200 (NMY34_04200) 831421..832854 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
NMY34_RS04205 (NMY34_04205) 832973..833701 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
NMY34_RS04210 (NMY34_04210) 833751..834062 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
NMY34_RS04215 (NMY34_04215) 834226..834885 + 660 WP_002916317.1 hemolysin III family protein -
NMY34_RS04220 (NMY34_04220) 835036..836019 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
NMY34_RS04225 (NMY34_04225) 836265..836531 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
NMY34_RS04230 (NMY34_04230) 836512..836922 + 411 WP_002916310.1 protein YgfX Toxin
NMY34_RS04235 (NMY34_04235) 836929..837450 - 522 WP_002916308.1 flavodoxin FldB -
NMY34_RS04240 (NMY34_04240) 837551..838447 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
NMY34_RS04245 (NMY34_04245) 838470..839183 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NMY34_RS04250 (NMY34_04250) 839189..840922 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T252263 WP_002916310.1 NZ_CP101546:836512-836922 [Klebsiella pneumoniae subsp. pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT252263 WP_002916312.1 NZ_CP101546:836265-836531 [Klebsiella pneumoniae subsp. pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References