Detailed information of TA system TA025226

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/AbrB(antitoxin)
• Location: 1543237..1543615
• Replicon: chromosome
• Accession: NC_015518
• Organism: Acidianus hospitalis W1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: AHOS_RS13490
• Protein ID: WP_013776505.1
• Coordinates: 1543451..1543615 (+)
• Length: 55 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: F4B6G9
• Locus tag: AHOS_RS08920
• Protein ID: WP_013776504.1
• Coordinates: 1543237..1543470 (+)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AHOS_RS12575	1538480..1538662	+	183	WP_245527058.1	HEPN domain-containing protein	-
AHOS_RS12825	1538892..1539050	+	159	WP_187287256.1	hypothetical protein	-
AHOS_RS08895 (Ahos_1709)	1539122..1540258	-	1137	WP_013776501.1	hypothetical protein	-
AHOS_RS08900	1540293..1540756	-	464	Protein_1780	transposase	-
AHOS_RS08905 (Ahos_1711)	1540990..1542297	-	1308	WP_013776503.1	mercury(II) reductase	-
AHOS_RS08910	1542294..1542446	-	153	WP_048054720.1	TA0938 family protein	-
AHOS_RS13485	1542706..1542834	+	129	WP_280956823.1	hypothetical protein	-
AHOS_RS08920 (Ahos_1712)	1543237..1543470	+	234	WP_013776504.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
AHOS_RS13490 (Ahos_1713)	1543451..1543615	+	165	WP_013776505.1	PIN domain-containing protein	Toxin
AHOS_RS08925	1543579..1543839	+	261	WP_280956825.1	PIN domain-containing protein	-
AHOS_RS08930 (Ahos_1714)	1544178..1545173	+	996	WP_013776506.1	alcohol dehydrogenase catalytic domain-containing protein	-
AHOS_RS08935 (Ahos_1715)	1545268..1546035	-	768	WP_013776507.1	formate dehydrogenase accessory sulfurtransferase FdhD	-
AHOS_RS08940 (Ahos_1716)	1546010..1546372	-	363	WP_013776508.1	DUF1641 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-48)

Antitoxin

• SpoVT-AbrB domain (3-47)

Sequences

Toxin

Protein

• Length: 55 a.a.
• Molecular weight: 6286.30 Da
• Isoelectric Point: 4.1725

>T25226 WP_013776505.1 NC_015518:1543451-1543615 [Acidianus hospitalis W1]
MIIVDTNVLVYSTFEDSENHSKALEIVEKEDVKIPQIVAYEFLWVLAKLTQMFP

Nucleotide

• Length: 165 bp

>T25226 NC_015518:1543451-1543615 [Acidianus hospitalis W1]
ATGATAATAGTAGATACTAACGTATTAGTTTATTCTACTTTTGAAGATTCAGAAAACCATTCTAAAGCTTTAGAAATCGT
GGAGAAGGAGGACGTTAAAATTCCGCAGATAGTAGCTTATGAGTTCTTATGGGTTTTAGCAAAACTTACGCAAATGTTTC
CTTAA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8991.26 Da
• Isoelectric Point: 6.3526

>AT25226 WP_013776504.1 NC_015518:1543237-1543470 [Acidianus hospitalis W1]
VKVKVTRNFQVTIPSEIREKLGIKEGDYVEVTLDESNGVIIIKPYIRKWTTIRLNRKVDQEDIDKAVEEALNDNSRY

Nucleotide

• Length: 234 bp

>AT25226 NC_015518:1543237-1543470 [Acidianus hospitalis W1]
GTGAAGGTAAAGGTTACTAGAAACTTTCAAGTTACTATACCTTCAGAGATAAGAGAAAAATTAGGTATAAAGGAAGGGGA
TTACGTGGAAGTAACTTTAGATGAAAGTAATGGGGTTATAATAATTAAACCGTACATAAGAAAGTGGACTACAATAAGAT
TGAATAGAAAAGTGGATCAAGAGGATATAGATAAGGCAGTTGAGGAGGCATTAAATGATAATAGTAGATACTAA

Structures

Antitoxin

• AlphaFold DB: F4B6G9