252259

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 2084..2558 Replicon plasmid p21_3
Accession NZ_CP101545
Organism Klebsiella pneumoniae subsp. pneumoniae strain KP21

Toxin (Protein)


Gene name pasB Uniprot ID A0A8J3DT22
Locus tag NMY29_RS27995 Protein ID WP_004197762.1
Coordinates 2292..2558 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID S1EJF5
Locus tag NMY29_RS27990 Protein ID WP_000879771.1
Coordinates 2084..2308 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMY29_RS27975 (NMY29_27955) 220..654 + 435 Protein_1 relaxase/mobilization nuclease domain-containing protein -
NMY29_RS27980 (NMY29_27960) 689..1198 + 510 WP_032433972.1 MbeB family mobilization protein -
NMY29_RS27985 (NMY29_27965) 1205..1417 + 213 WP_021527181.1 MbeD family mobilization/exclusion protein -
NMY29_RS27990 (NMY29_27970) 2084..2308 + 225 WP_000879771.1 DUF6290 family protein Antitoxin
NMY29_RS27995 (NMY29_27975) 2292..2558 + 267 WP_004197762.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NMY29_RS28000 (NMY29_27980) 2628..2978 - 351 WP_004197756.1 hypothetical protein -
NMY29_RS28005 (NMY29_27985) 3044..3589 - 546 WP_023317533.1 hypothetical protein -
NMY29_RS28010 (NMY29_27990) 3615..3941 - 327 WP_050516389.1 hypothetical protein -
NMY29_RS28015 (NMY29_27995) 5097..5273 + 177 WP_004197757.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..5596 5596


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Relaxosome protein TraY

(4-45)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10342.96 Da        Isoelectric Point: 9.8727

>T252259 WP_004197762.1 NZ_CP101545:2292-2558 [Klebsiella pneumoniae subsp. pneumoniae]
MVWTINYSDRALKSLRKMDKQNARRIVDFMSLRIAVAADPRQSGKPLKGELGEFWRYRVGDYRVLCEIRDDELVILAATI
GHRREVYD

Download         Length: 267 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8369.28 Da        Isoelectric Point: 4.6533

>AT252259 WP_000879771.1 NZ_CP101545:2084-2308 [Klebsiella pneumoniae subsp. pneumoniae]
MLAIRLSDEIESRLDSLAKQTGRTKTFYAREAILAHLEDLEDYYLSAETAARVRRGDEAVHSSEDVRKSLGLDD

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB S1EJF5

References