Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 6033..6613 Replicon plasmid p21_2
Accession NZ_CP101544
Organism Klebsiella pneumoniae subsp. pneumoniae strain KP21

Toxin (Protein)


Gene name parE Uniprot ID A0A8J3DTL7
Locus tag NMY29_RS27940 Protein ID WP_071177730.1
Coordinates 6033..6347 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2X1PRM1
Locus tag NMY29_RS27945 Protein ID WP_000093040.1
Coordinates 6335..6613 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMY29_RS27920 (NMY29_27900) 1976..3940 + 1965 WP_071177727.1 TraM recognition domain-containing protein -
NMY29_RS27925 (NMY29_27905) 3940..4671 + 732 WP_071177728.1 MobC family replication-relaxation protein -
NMY29_RS27930 (NMY29_27910) 5236..5415 - 180 WP_000165970.1 Rop family plasmid primer RNA-binding protein -
NMY29_RS27935 (NMY29_27915) 5441..5869 - 429 WP_001140599.1 hypothetical protein -
NMY29_RS27940 (NMY29_27920) 6033..6347 - 315 WP_071177730.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NMY29_RS27945 (NMY29_27925) 6335..6613 - 279 WP_000093040.1 CopG family ribbon-helix-helix protein Antitoxin
NMY29_RS27950 (NMY29_27930) 6788..7153 - 366 WP_072354022.1 TonB family protein -
NMY29_RS27955 (NMY29_27935) 7150..7521 - 372 WP_001237044.1 cell envelope integrity protein TolA -
NMY29_RS27960 (NMY29_27940) 7795..8040 - 246 WP_032440458.1 hypothetical protein -
NMY29_RS27965 (NMY29_27945) 8367..10052 + 1686 WP_032440457.1 colicin-like bacteriocin tRNase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..10061 10061


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-96)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11805.73 Da        Isoelectric Point: 9.8324

>T252258 WP_071177730.1 NZ_CP101544:c6347-6033 [Klebsiella pneumoniae subsp. pneumoniae]
MPQVTISALAQRDLQRLQDFLKTKNRLAARKGGEVIVRAIQQLKTLPDIGRPVPFLPLEYKELVIGFGDSGYVMLYRHDR
EMDQIVIVTVRHQKESGYPGADSL

Download         Length: 315 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10709.73 Da        Isoelectric Point: 4.7561

>AT252258 WP_000093040.1 NZ_CP101544:c6613-6335 [Klebsiella pneumoniae subsp. pneumoniae]
MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEKRSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWG
TENEQDAPPCHR

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2X1PRM1

References