Detailed information of TA system TA025225

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/HTH_10(toxin)
• Location: 1505258..1506231
• Replicon: chromosome
• Accession: NC_015518
• Organism: Acidianus hospitalis W1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: F4B6C5
• Locus tag: AHOS_RS08680
• Protein ID: WP_013776460.1
• Coordinates: 1505620..1506231 (+)
• Length: 204 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: F4B6C4
• Locus tag: AHOS_RS08675
• Protein ID: WP_013776459.1
• Coordinates: 1505258..1505602 (+)
• Length: 115 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AHOS_RS08645 (Ahos_1661)	1500656..1501213	+	558	WP_013776454.1	carbonic anhydrase	-
AHOS_RS08650 (Ahos_1662)	1501214..1502341	-	1128	WP_013776455.1	ATP-binding protein	-
AHOS_RS08655 (Ahos_1663)	1503040..1503540	-	501	WP_148230311.1	PIN domain-containing protein	-
AHOS_RS08660 (Ahos_1664)	1503525..1503941	-	417	WP_013776457.1	hypothetical protein	-
AHOS_RS12975	1504176..1504707	+	532	Protein_1731	DUF4322 domain-containing protein	-
AHOS_RS08675 (Ahos_1666)	1505258..1505602	+	345	WP_013776459.1	DUF488 domain-containing protein	Antitoxin
AHOS_RS08680 (Ahos_1667)	1505620..1506231	+	612	WP_013776460.1	helix-turn-helix domain-containing protein	Toxin
AHOS_RS08685 (Ahos_1668)	1506911..1507654	+	744	WP_013776461.1	hypothetical protein	-
AHOS_RS08690 (Ahos_1669)	1507883..1508845	-	963	WP_013776462.1	CBS domain-containing protein	-
AHOS_RS08695 (Ahos_1670)	1509671..1511221	-	1551	WP_013776463.1	PQQ-like beta-propeller repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1504335..1504583	248

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Bacterioopsin activator-type, HTH domain (145-197)

Antitoxin

• Protein of unknown function DUF488 (3-108)

Sequences

Toxin

Protein

• Length: 204 a.a.
• Molecular weight: 23007.06 Da
• Isoelectric Point: 9.4668

>T25225 WP_013776460.1 NC_015518:1505620-1506231 [Acidianus hospitalis W1]
MYRSPFEVTLLIEDHPCEVMKIISLAGLKASVENVKLGEQTTDHIVSFEKEIGKNEVLKLKSNSVKVLKLSETKVWVRTN
GCAVCRILYTSDIVVEKIKVLKERTLLYTLLVLASSSFNEFLTKLSKEGVKVTVLNVSEISSAELTKRQMEILQLAYKLG
YFNDERGITLSQLADKLGISAPTLEEILRRALRKVVKYYLDKH

Nucleotide

• Length: 612 bp

>T25225 NC_015518:1505620-1506231 [Acidianus hospitalis W1]
ATGTATAGATCTCCCTTTGAAGTAACATTACTAATAGAGGATCACCCTTGTGAAGTAATGAAAATAATATCATTAGCAGG
ACTTAAGGCGAGTGTGGAGAACGTTAAGTTAGGAGAACAGACTACGGACCATATAGTTAGTTTCGAAAAGGAGATAGGGA
AGAATGAAGTTCTAAAATTAAAGTCAAATAGCGTTAAAGTGCTAAAACTCAGTGAAACTAAAGTATGGGTGAGAACTAAT
GGATGTGCAGTATGCAGGATACTTTATACTTCTGATATAGTTGTAGAGAAAATTAAAGTACTAAAAGAGAGGACTTTACT
CTACACTTTACTTGTACTTGCTAGCTCATCATTTAATGAATTTTTAACCAAATTATCGAAAGAAGGAGTAAAAGTAACAG
TCTTGAACGTCTCGGAGATATCTAGCGCAGAACTAACTAAGAGGCAGATGGAAATTCTCCAATTAGCATACAAGCTAGGC
TATTTTAATGACGAAAGGGGCATTACATTATCTCAGTTAGCGGATAAGTTGGGAATAAGTGCTCCGACTTTAGAGGAGAT
ATTAAGGAGAGCTCTTAGAAAAGTTGTAAAGTATTATTTGGATAAACACTAA

Antitoxin

Protein

• Length: 115 a.a.
• Molecular weight: 13727.05 Da
• Isoelectric Point: 10.1158

>AT25225 WP_013776459.1 NC_015518:1505258-1505602 [Acidianus hospitalis W1]
MIKVKRVYDPLEKDDGIRILVDRLWPRGVKKDQVDVWLKDVAPSDELRRWYNHKPEKWEEFKRKYFEELSRNPKVEILLQ
LIKKGNNVTLLYASKSPYNNAVALKEYLEKILKV

Nucleotide

• Length: 345 bp

>AT25225 NC_015518:1505258-1505602 [Acidianus hospitalis W1]
ATGATAAAAGTTAAGAGAGTTTACGATCCTTTAGAAAAGGATGATGGAATTAGGATTTTAGTAGACAGATTATGGCCTAG
AGGTGTTAAGAAGGATCAAGTAGACGTTTGGCTTAAGGACGTAGCCCCTAGTGATGAACTAAGGAGATGGTATAATCACA
AACCTGAAAAATGGGAGGAGTTTAAAAGGAAGTACTTTGAGGAACTCAGTAGAAATCCTAAGGTTGAAATACTCTTACAG
TTAATTAAAAAGGGGAATAATGTAACCTTACTTTATGCCTCAAAATCTCCATATAATAATGCGGTTGCATTAAAAGAGTA
TTTAGAGAAGATATTAAAGGTTTGA

Structures

Toxin

• AlphaFold DB: F4B6C5

Antitoxin

• AlphaFold DB: F4B6C4