Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4916800..4917316 Replicon chromosome
Accession NZ_CP101542
Organism Klebsiella pneumoniae subsp. pneumoniae strain KP21

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag NMY29_RS24355 Protein ID WP_002886902.1
Coordinates 4916800..4917084 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag NMY29_RS24360 Protein ID WP_002886901.1
Coordinates 4917074..4917316 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMY29_RS24330 (NMY29_24310) 4912284..4912547 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
NMY29_RS24335 (NMY29_24315) 4912677..4912850 + 174 WP_002886906.1 hypothetical protein -
NMY29_RS24340 (NMY29_24320) 4912853..4913596 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
NMY29_RS24345 (NMY29_24325) 4913953..4916091 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
NMY29_RS24350 (NMY29_24330) 4916332..4916796 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NMY29_RS24355 (NMY29_24335) 4916800..4917084 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NMY29_RS24360 (NMY29_24340) 4917074..4917316 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NMY29_RS24365 (NMY29_24345) 4917394..4919304 - 1911 WP_004152270.1 PRD domain-containing protein -
NMY29_RS24370 (NMY29_24350) 4919327..4920481 - 1155 WP_002886900.1 lactonase family protein -
NMY29_RS24375 (NMY29_24355) 4920547..4921287 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T252248 WP_002886902.1 NZ_CP101542:c4917084-4916800 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT252248 WP_002886901.1 NZ_CP101542:c4917316-4917074 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References