Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4813508..4814318 Replicon chromosome
Accession NZ_CP101542
Organism Klebsiella pneumoniae subsp. pneumoniae strain KP21

Toxin (Protein)


Gene name KacT Uniprot ID A0A0H3GMP0
Locus tag NMY29_RS23860 Protein ID WP_002887280.1
Coordinates 4813508..4814041 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag NMY29_RS23865 Protein ID WP_002887278.1
Coordinates 4814052..4814318 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMY29_RS23855 (NMY29_23835) 4812339..4813460 + 1122 WP_002887282.1 cupin domain-containing protein -
NMY29_RS23860 (NMY29_23840) 4813508..4814041 - 534 WP_002887280.1 type II toxin-antitoxin system toxin KacT Toxin
NMY29_RS23865 (NMY29_23845) 4814052..4814318 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
NMY29_RS23870 (NMY29_23850) 4814421..4815854 - 1434 WP_002887275.1 Cu(+)/Ag(+) sensor histidine kinase -
NMY29_RS23875 (NMY29_23855) 4815844..4816527 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
NMY29_RS23880 (NMY29_23860) 4816699..4818084 + 1386 WP_002887267.1 efflux transporter outer membrane subunit -
NMY29_RS23885 (NMY29_23865) 4818102..4818446 + 345 WP_002887266.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19838.70 Da        Isoelectric Point: 5.2614

>T252247 WP_002887280.1 NZ_CP101542:c4814041-4813508 [Klebsiella pneumoniae subsp. pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHVMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT252247 WP_002887278.1 NZ_CP101542:c4814318-4814052 [Klebsiella pneumoniae subsp. pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5ZGN
PDB 5XUN

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References