252235

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 4804372..4804980 Replicon chromosome
Accession NZ_CP101540
Organism Pseudomonas aeruginosa strain D-2

Toxin (Protein)


Gene name PfiT Uniprot ID A0A1B1XUZ2
Locus tag NNL25_RS22415 Protein ID WP_003123043.1
Coordinates 4804372..4804719 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag NNL25_RS22420 Protein ID WP_003114155.1
Coordinates 4804729..4804980 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NNL25_RS22385 (NNL25_22355) 4799731..4800003 + 273 WP_003134390.1 cysteine-rich CWC family protein -
NNL25_RS22390 (NNL25_22360) 4800003..4800695 + 693 WP_003085458.1 16S rRNA pseudouridine(516) synthase -
NNL25_RS22395 (NNL25_22365) 4800831..4801874 + 1044 WP_255865873.1 L,D-transpeptidase -
NNL25_RS22400 (NNL25_22370) 4801954..4802691 + 738 WP_003085453.1 murein L,D-transpeptidase catalytic domain family protein -
NNL25_RS22405 (NNL25_22375) 4803143..4804045 + 903 WP_003085447.1 (R)-3-hydroxydecanoyl-ACP:CoA transacylase -
NNL25_RS22415 (NNL25_22385) 4804372..4804719 - 348 WP_003123043.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NNL25_RS22420 (NNL25_22390) 4804729..4804980 - 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NNL25_RS22425 (NNL25_22395) 4805194..4806177 - 984 WP_043178114.1 tyrosine-type recombinase/integrase -
NNL25_RS22430 (NNL25_22400) 4806177..4807469 - 1293 WP_128711093.1 hypothetical protein -
NNL25_RS22435 (NNL25_22405) 4807728..4808990 - 1263 WP_223683530.1 zonular occludens toxin domain-containing protein -
NNL25_RS22440 (NNL25_22410) 4808992..4809342 - 351 WP_003133726.1 DUF2523 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage catB7 - 4804372..4826203 21831


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12990.74 Da        Isoelectric Point: 4.4212

>T252235 WP_003123043.1 NZ_CP101540:c4804719-4804372 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAAFQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEAAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT252235 WP_003114155.1 NZ_CP101540:c4804980-4804729 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1XUZ2

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References