252234

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4515032..4515672 Replicon chromosome
Accession NZ_CP101540
Organism Pseudomonas aeruginosa strain D-2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NNL25_RS21020 Protein ID WP_003105740.1
Coordinates 4515032..4515442 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag NNL25_RS21025 Protein ID WP_031634724.1
Coordinates 4515442..4515672 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NNL25_RS20980 (NNL25_20950) 4510926..4511177 - 252 WP_255865365.1 hypothetical protein -
NNL25_RS20985 (NNL25_20955) 4511254..4511982 + 729 WP_023123987.1 TIGR03761 family integrating conjugative element protein -
NNL25_RS20990 (NNL25_20960) 4511988..4512536 + 549 WP_223720502.1 DUF3158 family protein -
NNL25_RS20995 (NNL25_20965) 4512584..4513414 + 831 WP_023132184.1 Rha family transcriptional regulator -
NNL25_RS21000 (NNL25_20970) 4513444..4513932 + 489 WP_034038749.1 single-stranded DNA-binding protein -
NNL25_RS21005 (NNL25_20975) 4514100..4514267 + 168 WP_128729268.1 CrpP family ICE-associated protein -
NNL25_RS21010 (NNL25_20980) 4514333..4514551 - 219 WP_003105747.1 hypothetical protein -
NNL25_RS21015 (NNL25_20985) 4514750..4515010 - 261 WP_003105742.1 hypothetical protein -
NNL25_RS21020 (NNL25_20990) 4515032..4515442 - 411 WP_003105740.1 tRNA(fMet)-specific endonuclease VapC Toxin
NNL25_RS21025 (NNL25_20995) 4515442..4515672 - 231 WP_031634724.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NNL25_RS21030 (NNL25_21000) 4515990..4517909 + 1920 WP_150020274.1 type I DNA topoisomerase -
NNL25_RS21035 (NNL25_21005) 4517983..4518453 + 471 WP_071535142.1 hypothetical protein -
NNL25_RS21040 (NNL25_21010) 4519109..4520271 + 1163 WP_086008657.1 IS3-like element IS222 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 4498896..4539924 41028


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(7-33)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15450.81 Da        Isoelectric Point: 7.3233

>T252234 WP_003105740.1 NZ_CP101540:c4515442-4515032 [Pseudomonas aeruginosa]
MLKFMLDTNICIFTIKNRPQEVREAFLRHHDQMCISTVTLMELIYGAEKSSNPSRNLADVEGFAARLEVLKYDQEAAAHT
GQLRAELARLGKQIGPYDQMIAGHARSQGLIVVTNNRREFDRVPGLRVEDWVVPIV

Download         Length: 411 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8420.29 Da        Isoelectric Point: 4.2821

>AT252234 WP_031634724.1 NZ_CP101540:c4515672-4515442 [Pseudomonas aeruginosa]
VEQGSVFQSNRSQAVRLPKAVALPDDVKRVDVVAVGRARIITPAGESWDSWFDGEGVTADFMAEREQPADQERETF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References