Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/- |
Location | 3508753..3509974 | Replicon | chromosome |
Accession | NZ_CP101540 | ||
Organism | Pseudomonas aeruginosa strain D-2 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | - |
Locus tag | NNL25_RS16240 | Protein ID | WP_003114949.1 |
Coordinates | 3509396..3509974 (+) | Length | 193 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | - |
Locus tag | NNL25_RS16235 | Protein ID | WP_003088112.1 |
Coordinates | 3508753..3509307 (+) | Length | 185 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
NNL25_RS16210 (NNL25_16190) | 3504321..3504872 | + | 552 | WP_003102727.1 | XRE family transcriptional regulator | - |
NNL25_RS16215 (NNL25_16195) | 3504869..3505267 | - | 399 | WP_003088123.1 | NADH-quinone oxidoreductase subunit A | - |
NNL25_RS16220 (NNL25_16200) | 3505280..3505603 | - | 324 | WP_003102734.1 | multidrug efflux SMR transporter | - |
NNL25_RS16225 (NNL25_16205) | 3505934..3506395 | + | 462 | WP_003102736.1 | (2Fe-2S)-binding protein | - |
NNL25_RS16230 (NNL25_16210) | 3506400..3508595 | + | 2196 | WP_034071052.1 | xanthine dehydrogenase family protein molybdopterin-binding subunit | - |
NNL25_RS16235 (NNL25_16215) | 3508753..3509307 | + | 555 | WP_003088112.1 | helix-turn-helix transcriptional regulator | Antitoxin |
NNL25_RS16240 (NNL25_16220) | 3509396..3509974 | + | 579 | WP_003114949.1 | HD domain-containing protein | Toxin |
NNL25_RS16245 (NNL25_16225) | 3510082..3511269 | - | 1188 | WP_003102741.1 | HlyD family efflux transporter periplasmic adaptor subunit | - |
NNL25_RS16250 (NNL25_16230) | 3511259..3513430 | - | 2172 | WP_003114950.1 | type I secretion system permease/ATPase | - |
NNL25_RS16255 (NNL25_16235) | 3513420..3514697 | - | 1278 | WP_003102743.1 | TolC family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21897.75 Da Isoelectric Point: 5.3655
>T252232 WP_003114949.1 NZ_CP101540:3509396-3509974 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA
Download Length: 579 bp
Antitoxin
Download Length: 185 a.a. Molecular weight: 20454.63 Da Isoelectric Point: 8.1590
>AT252232 WP_003088112.1 NZ_CP101540:3508753-3509307 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
Download Length: 555 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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