Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/-
Location 3508753..3509974 Replicon chromosome
Accession NZ_CP101540
Organism Pseudomonas aeruginosa strain D-2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NNL25_RS16240 Protein ID WP_003114949.1
Coordinates 3509396..3509974 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag NNL25_RS16235 Protein ID WP_003088112.1
Coordinates 3508753..3509307 (+) Length 185 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NNL25_RS16210 (NNL25_16190) 3504321..3504872 + 552 WP_003102727.1 XRE family transcriptional regulator -
NNL25_RS16215 (NNL25_16195) 3504869..3505267 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
NNL25_RS16220 (NNL25_16200) 3505280..3505603 - 324 WP_003102734.1 multidrug efflux SMR transporter -
NNL25_RS16225 (NNL25_16205) 3505934..3506395 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
NNL25_RS16230 (NNL25_16210) 3506400..3508595 + 2196 WP_034071052.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
NNL25_RS16235 (NNL25_16215) 3508753..3509307 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
NNL25_RS16240 (NNL25_16220) 3509396..3509974 + 579 WP_003114949.1 HD domain-containing protein Toxin
NNL25_RS16245 (NNL25_16225) 3510082..3511269 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
NNL25_RS16250 (NNL25_16230) 3511259..3513430 - 2172 WP_003114950.1 type I secretion system permease/ATPase -
NNL25_RS16255 (NNL25_16235) 3513420..3514697 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(16-170)

Antitoxin

(14-62)


Sequences


Toxin        


Download         Length: 193 a.a.        Molecular weight: 21897.75 Da        Isoelectric Point: 5.3655

>T252232 WP_003114949.1 NZ_CP101540:3509396-3509974 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA

Download         Length: 579 bp


Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT252232 WP_003088112.1 NZ_CP101540:3508753-3509307 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References