Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 613577..614214 Replicon chromosome
Accession NZ_CP101540
Organism Pseudomonas aeruginosa strain D-2

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag NNL25_RS02885 Protein ID WP_019725766.1
Coordinates 613577..613759 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NNL25_RS02890 Protein ID WP_019725767.1
Coordinates 613792..614214 (+) Length 141 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NNL25_RS02865 (NNL25_02865) 610557..610700 + 144 WP_153574913.1 hypothetical protein -
NNL25_RS02870 (NNL25_02870) 610991..611362 - 372 WP_003142777.1 nuclease-related domain-containing protein -
NNL25_RS02875 (NNL25_02875) 611455..612576 - 1122 WP_003117952.1 Fic family protein -
NNL25_RS02880 (NNL25_02880) 612835..612972 - 138 WP_003113217.1 hypothetical protein -
NNL25_RS02885 (NNL25_02885) 613577..613759 + 183 WP_019725766.1 type II toxin-antitoxin system HicA family toxin Toxin
NNL25_RS02890 (NNL25_02890) 613792..614214 + 423 WP_019725767.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NNL25_RS02895 (NNL25_02895) 614460..615431 - 972 WP_058171393.1 hypothetical protein -
NNL25_RS02900 (NNL25_02900) 615416..616108 - 693 WP_058171392.1 hypothetical protein -
NNL25_RS02905 (NNL25_02905) 616105..616647 - 543 WP_025982284.1 hypothetical protein -
NNL25_RS02910 (NNL25_02910) 616644..617567 - 924 WP_031633727.1 hypothetical protein -
NNL25_RS02915 (NNL25_02915) 617564..618040 - 477 WP_058171390.1 phage tail assembly chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 611455..664699 53244


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-62)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6970.07 Da        Isoelectric Point: 10.2954

>T252230 WP_019725766.1 NZ_CP101540:613577-613759 [Pseudomonas aeruginosa]
MKYSEFRRWLKARGVIFEPAKGSHFKVYYGDNQTIFPDHGAKEIGDGLRKKIIKDLGLKD

Download         Length: 183 bp

Antitoxin


Download         Length: 141 a.a.        Molecular weight: 14970.22 Da        Isoelectric Point: 4.9047

>AT252230 WP_019725767.1 NZ_CP101540:613792-614214 [Pseudomonas aeruginosa]
MFDYPVTVHEEAGSVWVSCDDVPEMASAGDTVDEALLDAVEGLESALSLYVDRRQSIPLPSKGKAGQSIVRLPALTSAKI
ALWNTMLAQNVGKAELARRLGVNRVQVDRLVDLLHGSKIEAVEHALAILGQRLAVTVIAA

Download         Length: 423 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References