Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 142419..142924 Replicon chromosome
Accession NZ_CP101540
Organism Pseudomonas aeruginosa strain D-2

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag NNL25_RS00650 Protein ID WP_003083773.1
Coordinates 142419..142700 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag NNL25_RS00655 Protein ID WP_003083775.1
Coordinates 142697..142924 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NNL25_RS00625 (NNL25_00625) 137670..139019 + 1350 WP_255868171.1 C4-dicarboxylate transporter DctA -
NNL25_RS00630 (NNL25_00630) 139068..139754 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
NNL25_RS00635 (NNL25_00635) 139855..140589 + 735 WP_003117208.1 GntR family transcriptional regulator -
NNL25_RS00640 (NNL25_00640) 140769..141179 + 411 WP_003101225.1 aegerolysin family protein -
NNL25_RS00645 (NNL25_00645) 141211..142119 - 909 WP_003083769.1 LysR family transcriptional regulator -
NNL25_RS00650 (NNL25_00650) 142419..142700 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
NNL25_RS00655 (NNL25_00655) 142697..142924 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
NNL25_RS00660 (NNL25_00660) 143100..143720 - 621 WP_003101226.1 hypothetical protein -
NNL25_RS00665 (NNL25_00665) 143821..144321 + 501 WP_003112629.1 LEA type 2 family protein -
NNL25_RS00670 (NNL25_00670) 144394..144735 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
NNL25_RS00675 (NNL25_00675) 144817..146244 - 1428 WP_255868176.1 GABA permease -
NNL25_RS00680 (NNL25_00680) 146413..147906 - 1494 WP_255868178.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T252229 WP_003083773.1 NZ_CP101540:c142700-142419 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT252229 WP_003083775.1 NZ_CP101540:c142924-142697 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References