Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2139801..2141311 Replicon chromosome
Accession NC_015508
Organism Agrobacterium sp. H13-3

Toxin (Protein)


Gene name HipA1 Uniprot ID F0LBK0
Locus tag AGROH133_RS23295 Protein ID WP_013762466.1
Coordinates 2140070..2141311 (+) Length 414 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID F0LBJ9
Locus tag AGROH133_RS23290 Protein ID WP_013762465.1
Coordinates 2139801..2140073 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AGROH133_RS23255 2134887..2135288 - 402 WP_013762456.1 hypothetical protein -
AGROH133_RS23260 2135327..2135542 - 216 WP_019567388.1 hypothetical protein -
AGROH133_RS23265 2136206..2136865 - 660 WP_013762458.1 porin family protein -
AGROH133_RS23270 2137112..2137456 - 345 WP_013762459.1 ester cyclase -
AGROH133_RS23275 2137527..2138147 - 621 WP_025594779.1 phosphoglycerate mutase family protein -
AGROH133_RS23280 2138125..2138694 - 570 Protein_1872 AAA family ATPase -
AGROH133_RS27245 2139059..2139379 - 321 WP_013762464.1 hypothetical protein -
AGROH133_RS23290 2139801..2140073 + 273 WP_013762465.1 helix-turn-helix transcriptional regulator Antitoxin
AGROH133_RS23295 2140070..2141311 + 1242 WP_013762466.1 type II toxin-antitoxin system HipA family toxin Toxin
AGROH133_RS27855 2141301..2141441 + 141 WP_156390030.1 hypothetical protein -
AGROH133_RS23305 2142464..2143558 + 1095 WP_013762468.1 helix-turn-helix transcriptional regulator -
AGROH133_RS23315 2144930..2145202 + 273 WP_029658823.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
AGROH133_RS27550 2145483..2145692 + 210 WP_139104336.1 hypothetical protein -
AGROH133_RS23320 2145918..2146160 + 243 WP_003518907.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(9-66)


Sequences

Toxin        


Download         Length: 414 a.a.        Molecular weight: 45352.22 Da        Isoelectric Point: 7.8873

>T25221 WP_013762466.1 NC_015508:2140070-2141311 [Agrobacterium fabacearum]
MTTIYYETLPVAHLTFEGEWRLDYDPGWEARRPAFPVSLTMPLRSGSVGAAKLLPWLANLLPETHLAEIGQRFKVSPQDI
VGLLAHIGRDTAGALSIGEPRKAGVNLRPVPDEQALERILNELPAKPFLVGERGVSMSLAGVQEKLPVFVDGNGRISVPV
DGTPSTHILKPDTKRLAGSVENEAFCLSLARACGLEAAEATIGVAGKRRYLLVKRYDRFTDPQGEIRRLHQEDLCQLTGC
FPSQKYERSSTGRGVTMKMMFDAVSDLVSPGERLKLLDAVIFNVLICNSDSHAKNYSILIGAGGSAKMAPLYDLMCAAVY
RQVDQSLPQGIFGRFHAPDLRRADWQALADDIGLSGASTLKRVGELAKLVSVACDEVAPYIVALSSDPTRILERITHSVQ
KRCRRIQEQMHDR

Download         Length: 1242 bp

>T25221 NC_015508:2140070-2141311 [Agrobacterium fabacearum]
ATGACAACCATCTACTACGAGACCTTGCCTGTCGCCCATCTGACTTTTGAAGGCGAATGGAGGTTGGACTATGATCCGGG
CTGGGAAGCGCGCCGCCCGGCCTTTCCGGTGTCGCTTACCATGCCGCTGCGTTCCGGATCCGTAGGTGCAGCGAAGCTGC
TTCCCTGGCTTGCCAATCTGCTTCCGGAAACCCATCTTGCCGAGATCGGTCAGCGCTTCAAGGTTTCCCCGCAAGATATT
GTCGGTCTACTTGCTCATATCGGACGTGACACGGCGGGGGCACTGTCGATCGGGGAGCCGCGCAAAGCTGGCGTCAACCT
CCGGCCGGTGCCGGACGAGCAGGCGCTGGAGCGTATTCTCAATGAACTTCCTGCCAAACCCTTTCTGGTCGGAGAGCGCG
GTGTTTCCATGTCGCTTGCTGGCGTCCAGGAGAAACTGCCGGTGTTTGTTGACGGGAACGGCCGTATTTCAGTTCCGGTT
GATGGGACGCCATCCACGCATATTCTCAAGCCGGATACGAAACGCCTTGCGGGGAGCGTGGAGAACGAAGCCTTTTGCCT
GTCGCTTGCACGTGCCTGCGGTCTTGAGGCTGCCGAGGCGACGATCGGAGTAGCTGGCAAGCGGCGTTATCTTCTCGTGA
AACGCTATGATCGCTTCACCGACCCTCAAGGCGAGATCCGCAGGTTGCATCAGGAGGATCTTTGCCAGTTAACCGGTTGC
TTCCCCTCGCAGAAATACGAGCGATCCTCGACCGGCCGCGGCGTGACCATGAAGATGATGTTTGACGCCGTCAGCGATCT
TGTTTCGCCTGGCGAGCGGTTGAAACTTCTCGATGCGGTGATCTTCAATGTCCTGATCTGCAATTCGGATTCGCATGCCA
AAAATTACTCTATCCTGATTGGTGCCGGTGGGTCCGCGAAGATGGCTCCACTCTATGACCTGATGTGCGCTGCCGTTTAT
CGCCAGGTCGACCAGAGCCTGCCGCAGGGGATTTTCGGTCGGTTCCATGCGCCTGACCTGCGGCGTGCCGACTGGCAGGC
ACTGGCTGATGACATTGGATTGAGCGGCGCATCGACACTGAAACGGGTGGGGGAGCTTGCAAAACTGGTCAGCGTCGCAT
GCGATGAGGTGGCACCATATATCGTCGCCCTCTCCAGCGATCCGACGAGGATTCTTGAGCGAATTACTCACAGCGTTCAA
AAGCGGTGCCGGCGAATTCAGGAGCAGATGCATGATCGATGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9685.07 Da        Isoelectric Point: 6.2834

>AT25221 WP_013762465.1 NC_015508:2139801-2140073 [Agrobacterium fabacearum]
MFRSARDFGAAIKERRKALGWTQTGLAARSGTGERFIVELESGKPSCQLEKALIVARAVGIDLGDLKTVQTVQVASDDDL
GFLPMFGADQ

Download         Length: 273 bp

>AT25221 NC_015508:2139801-2140073 [Agrobacterium fabacearum]
ATGTTCAGGTCCGCGCGTGATTTCGGCGCTGCTATCAAGGAGAGACGCAAAGCACTTGGCTGGACGCAAACCGGTCTTGC
TGCCCGTTCCGGAACGGGGGAACGCTTCATCGTCGAGCTTGAATCGGGCAAGCCGAGTTGCCAGCTCGAAAAAGCCCTGA
TCGTCGCACGCGCAGTTGGAATCGATCTTGGCGATCTCAAGACGGTTCAGACTGTGCAAGTCGCGTCGGACGATGACCTC
GGCTTTTTGCCGATGTTTGGTGCTGATCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F0LBK0

Antitoxin

Source ID Structure
AlphaFold DB F0LBJ9

References