Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 743194..743969 Replicon chromosome
Accession NZ_CP101533
Organism Klebsiella pneumoniae strain FZKP4523

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag NNL33_RS03715 Protein ID WP_004150910.1
Coordinates 743484..743969 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag NNL33_RS03710 Protein ID WP_004150912.1
Coordinates 743194..743487 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NNL33_RS03690 738325..739236 + 912 WP_004188550.1 LysR family transcriptional regulator -
NNL33_RS03695 739237..740385 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
NNL33_RS03700 740396..741772 - 1377 WP_004217775.1 cystathionine beta-synthase -
NNL33_RS03710 743194..743487 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
NNL33_RS03715 743484..743969 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
NNL33_RS03720 744673..745266 + 594 WP_004188553.1 hypothetical protein -
NNL33_RS03725 745363..745579 + 217 Protein_732 transposase -
NNL33_RS03730 746185..747057 + 873 WP_004188557.1 ParA family protein -
NNL33_RS03735 747057..747440 + 384 WP_004150906.1 hypothetical protein -
NNL33_RS03740 747433..748800 + 1368 WP_004150905.1 SPI-7-type island replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 742151..745515 3364


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T252209 WP_004150910.1 NZ_CP101533:743484-743969 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT252209 WP_004150912.1 NZ_CP101533:743194-743487 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References