Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 2160406..2162254 Replicon plasmid pla_1
Accession NZ_CP101525
Organism Burkholderia arboris strain MEC_B345

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag NLX30_RS28195 Protein ID WP_256086191.1
Coordinates 2160406..2161317 (+) Length 304 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag NLX30_RS28200 Protein ID WP_059240106.1
Coordinates 2161397..2162254 (+) Length 286 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLX30_RS28165 (NLX30_28120) 2155796..2156875 - 1080 WP_059240094.1 porin -
NLX30_RS28170 (NLX30_28125) 2157312..2157629 + 318 WP_006489883.1 non-heme iron oxygenase ferredoxin subunit -
NLX30_RS28175 (NLX30_28130) 2157631..2157942 + 312 WP_059240097.1 hypothetical protein -
NLX30_RS28180 (NLX30_28135) 2157997..2159067 + 1071 WP_059240099.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
NLX30_RS28185 (NLX30_28140) 2159060..2159830 + 771 WP_256086190.1 SDR family oxidoreductase -
NLX30_RS28190 (NLX30_28145) 2159860..2160387 + 528 WP_059240103.1 cupin domain-containing protein -
NLX30_RS28195 (NLX30_28150) 2160406..2161317 + 912 WP_256086191.1 alpha/beta fold hydrolase Toxin
NLX30_RS28200 (NLX30_28155) 2161397..2162254 + 858 WP_059240106.1 IclR family transcriptional regulator Antitoxin
NLX30_RS28205 (NLX30_28160) 2162251..2163048 + 798 WP_174991282.1 SDR family oxidoreductase -
NLX30_RS28210 (NLX30_28165) 2163041..2164708 + 1668 WP_059240111.1 thiamine pyrophosphate-binding protein -
NLX30_RS28215 (NLX30_28170) 2164701..2165516 + 816 WP_059240112.1 aspartate dehydrogenase -
NLX30_RS28220 (NLX30_28175) 2165589..2167079 + 1491 WP_174991281.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - htpB / adeG / pchB / pchD / pmlI/bspI1 / pmlR/bspR1 / hsiC1/vipB / flgE / gnd 1..3525317 3525317


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(56-284)

Antitoxin

Transcription regulator IclR, N-terminal

(24-72)


Sequences

Toxin        


Download         Length: 304 a.a.        Molecular weight: 31062.30 Da        Isoelectric Point: 7.7324

>T252200 WP_256086191.1 NZ_CP101525:2160406-2161317 [Burkholderia arboris]
MSVIDKRERDRTAAFAALLGQFPEQRCAAGAAGTIGYREAGAGETGAQHAGRTLPVVLLHGIGSGAASWVRQLDTLGASR
RVLAWDAPGYGVSTPVHGASPAAADYAASLNAWLEALGIERCVLVGHSLGAIVAGGLARVMPARIAGLLLVSPAGGYGSA
PAETRESRRDARLAMLAELGPAGLAEQRSGNMLSGFANEEAKAWVRWNMARIVPAGYAQATHLLANADLATDLAGFRGRT
AVAVGANDAITPPAACERIAAAAHVALQVIPQAGHAGYVEAPAVYSALIDGFCRQCDQQRGLG

Download         Length: 912 bp

Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31416.88 Da        Isoelectric Point: 6.5058

>AT252200 WP_059240106.1 NZ_CP101525:2161397-2162254 [Burkholderia arboris]
MSEPLQQNESENAKAEANYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQSPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELHALYPEGALNRMTSATPETVDALYDMIREDALRGYGVSNSSFERGISVVTAPVRNETQRIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFLKALGLR

Download         Length: 858 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References