Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 73509..74150 Replicon plasmid pla_1
Accession NZ_CP101525
Organism Burkholderia arboris strain MEC_B345

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag NLX30_RS18615 Protein ID WP_059237391.1
Coordinates 73509..73847 (+) Length 113 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag NLX30_RS18620 Protein ID WP_256086647.1
Coordinates 73851..74150 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLX30_RS18605 (NLX30_18575) 70060..71493 - 1434 WP_256086646.1 aldehyde dehydrogenase family protein -
NLX30_RS18610 (NLX30_18580) 71523..73163 - 1641 WP_174993107.1 acetolactate synthase large subunit -
NLX30_RS18615 (NLX30_18585) 73509..73847 + 339 WP_059237391.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NLX30_RS18620 (NLX30_18590) 73851..74150 + 300 WP_256086647.1 putative addiction module antidote protein Antitoxin
NLX30_RS18625 (NLX30_18595) 74200..75486 - 1287 WP_256086648.1 DUF445 domain-containing protein -
NLX30_RS18630 (NLX30_18600) 75594..76814 - 1221 WP_256086649.1 anthranilate 1,2-dioxygenase system ferredoxin--NAD(+) reductase -
NLX30_RS18635 (NLX30_18605) 76804..77130 - 327 WP_059237394.1 anthranilate 1,2-dioxygenase ferredoxin subunit AndAb -
NLX30_RS18640 (NLX30_18610) 77148..77624 - 477 WP_175841486.1 anthranilate 1,2-dioxygenase small subunit AndAd -
NLX30_RS18645 (NLX30_18615) 77639..78910 - 1272 WP_059240780.1 anthranilate 1,2-dioxygenase large subunit AndAc -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - htpB / adeG / pchB / pchD / pmlI/bspI1 / pmlR/bspR1 / hsiC1/vipB / flgE / gnd 1..3525317 3525317


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(26-98)

Antitoxin

Cro/C1-type helix-turn-helix domain

(48-90)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12623.54 Da        Isoelectric Point: 9.9829

>T252198 WP_059237391.1 NZ_CP101525:73509-73847 [Burkholderia arboris]
MVDILQSVPYSAPTFSVRTTAVFDAWFAGLSDRIARRRIQARIDRLSMGNPGDWKSAGSPIVEMRIDHGPGYRVYYVRRG
MRWVILLCGGDKSTQQADIRAAHAMLAHLDME

Download         Length: 339 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10632.07 Da        Isoelectric Point: 6.9772

>AT252198 WP_256086647.1 NZ_CP101525:73851-74150 [Burkholderia arboris]
MDKIKTRPWDSAEHLKTADDMADYFDACLQEAGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGSKAHA

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References