Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 1981..2540 Replicon plasmid pHH194M-88K
Accession NZ_CP101515
Organism Escherichia coli strain HH194M

Toxin (Protein)


Gene name relE Uniprot ID U9YB49
Locus tag MOO21_RS23355 Protein ID WP_000421259.1
Coordinates 2265..2540 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U9Y625
Locus tag MOO21_RS23350 Protein ID WP_001178087.1
Coordinates 1981..2265 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOO21_RS23345 (46) 46..1077 + 1032 WP_000907852.1 plasmid replication initiator RepA -
MOO21_RS23350 (1981) 1981..2265 + 285 WP_001178087.1 ribbon-helix-helix domain-containing protein Antitoxin
MOO21_RS23355 (2265) 2265..2540 + 276 WP_000421259.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MOO21_RS23360 (2647) 2647..3621 - 975 WP_077141253.1 IS30 family transposase -
MOO21_RS23365 (3725) 3725..4645 - 921 WP_077141252.1 macrolide hydrolase EstT -
MOO21_RS23370 (4686) 4686..5642 + 957 WP_247193885.1 IS30-like element ISApl1 family transposase -
MOO21_RS23380 (6442) 6442..6921 - 480 WP_247193962.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..88459 88459


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10736.45 Da        Isoelectric Point: 9.9324

>T252182 WP_000421259.1 NZ_CP101515:2265-2540 [Escherichia coli]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELTGQTIY
VLRLWHTRENR

Download         Length: 276 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10488.92 Da        Isoelectric Point: 5.6558

>AT252182 WP_001178087.1 NZ_CP101515:1981-2265 [Escherichia coli]
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWIIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDNPLPVPR

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YB49

Antitoxin

Source ID Structure
AlphaFold DB U9Y625

References