Detailed information of TA system TA025218

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-CC2985
• Location: 39495..40029
• Replicon: plasmid 105.5R(r)p
• Accession: NC_015475
• Organism: Yersinia enterocolitica subsp. palearctica 105.5R(r)

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: YE105_RS20815
• Protein ID: WP_013749473.1
• Coordinates: 39495..39794 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: P0C2N3
• Locus tag: YE105_RS20820
• Protein ID: WP_005176524.1
• Coordinates: 39787..40029 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
YE105_RS20790	36075..36500	-	426	WP_010891235.1	type III secretion system chaperone SycH	-
YE105_RS22520	36704..37876	-	1173	Protein_46	IS3 family transposase	-
YE105_RS20805	38111..38503	-	393	WP_010891236.1	type III secretion system chaperone SycE/YerA	-
YE105_RS20810	38696..39355	+	660	WP_010891237.1	type III secretion system effector GTPase activator YopE	-
YE105_RS20815	39495..39794	-	300	WP_013749473.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
YE105_RS20820	39787..40029	-	243	WP_005176524.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
YE105_RS22525	40195..40487	-	293	Protein_51	IS6 family transposase	-
YE105_RS20825	40912..41877	-	966	WP_010891238.1	ParB/RepB/Spo0J family plasmid partition protein	-
YE105_RS20830	41874..43040	-	1167	WP_041852757.1	plasmid-partitioning protein SopA	-
YE105_RS20835	43656..44126	+	471	WP_010891240.1	hypothetical protein	-
YE105_RS20840	44187..44405	-	219	WP_013749479.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	yopK/yopQ / yopT / sycT / yopM / yopD / yopB / sycD/lcrH / lcrV / lcrG / lcrR / yscV/lcrD / yscY / yscX / sycN / tyeA / lcrE/yopN / yscN / yscO / yscQ / yscR / yscS / yscT / yscU / virG/yscW / yscB / yscC / yscD / yscE / yscF / yscG / yopR/yscH/lcrP / lcrO/yscI / ylpB/yscJ / yscK / yscL / lcrQ/yscM / yopH / sycH / sycE/yerA / yopE / yadA / yopO/ypkA / yopJ/yopP	1..69704	69704
	-	flank	IS/Tn	-	-	36826..37329	503

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• Antitoxin ParD (1-79)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11663.26 Da
• Isoelectric Point: 5.5497

>T25218 WP_013749473.1 NC_015475:c39794-39495 [Yersinia enterocolitica subsp. palearctica 105.5R(r)]
VYKLSELADEDIYNIASYTIRHFGVTQAKLYHENLAKVFELLAKNLELGAECNWICSDMRRFQYKKHGIYYITLSNDILI
SRVLHQSIDINAQDFPEYE

Nucleotide

• Length: 300 bp

>T25218 NC_015475:c39794-39495 [Yersinia enterocolitica subsp. palearctica 105.5R(r)]
GTGTATAAACTATCTGAACTGGCTGATGAGGATATTTATAATATTGCCAGTTATACTATCCGGCATTTCGGTGTGACTCA
GGCTAAGTTATACCATGAGAACTTGGCAAAGGTATTCGAGCTATTAGCTAAAAATCTAGAGTTAGGGGCTGAGTGTAACT
GGATTTGCTCTGACATGCGCCGTTTTCAGTATAAAAAGCACGGTATATACTATATAACGCTTAGCAATGATATTTTGATT
TCTCGAGTGCTGCATCAATCCATAGATATAAATGCTCAGGATTTTCCAGAGTATGAGTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8856.15 Da
• Isoelectric Point: 6.7232

>AT25218 WP_005176524.1 NC_015475:c40029-39787 [Yersinia enterocolitica subsp. palearctica 105.5R(r)]
MARVTSVTLGEHLTGFVGEMIQSGRYGNISEVLRDALRLMEAREQRVQHVRDMVLAGTNAPVSHRLMDEIFSAAVKDTSV

Nucleotide

• Length: 243 bp

>AT25218 NC_015475:c40029-39787 [Yersinia enterocolitica subsp. palearctica 105.5R(r)]
ATGGCTCGCGTAACCAGCGTAACACTTGGAGAGCATTTGACAGGTTTTGTGGGGGAAATGATTCAGTCTGGTCGTTATGG
CAATATATCAGAAGTGCTTCGTGATGCCTTAAGGCTAATGGAAGCACGTGAACAGCGTGTTCAACATGTACGCGATATGG
TGCTTGCAGGAACAAACGCACCTGTGAGCCATCGCTTAATGGATGAAATTTTTTCTGCTGCGGTGAAAGATACTAGTGTA
TAA

Structures

Antitoxin

• AlphaFold DB: A1JUB1