Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 52456..52991 Replicon plasmid pHH194M-140K
Accession NZ_CP101514
Organism Escherichia coli strain HH194M

Toxin (Protein)


Gene name relE Uniprot ID A0A0K4CX11
Locus tag MOO21_RS22895 Protein ID WP_000222771.1
Coordinates 52704..52991 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID T1PXV2
Locus tag MOO21_RS22890 Protein ID WP_001139206.1
Coordinates 52456..52707 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOO21_RS22885 (MOO21_22880) 47906..51796 - 3891 WP_247193929.1 helicase-related protein -
MOO21_RS22890 (MOO21_22885) 52456..52707 + 252 WP_001139206.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MOO21_RS22895 (MOO21_22890) 52704..52991 + 288 WP_000222771.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MOO21_RS22900 (MOO21_22895) 53359..53472 - 114 Protein_57 alkaline phosphatase -
MOO21_RS22905 (MOO21_22900) 53471..53676 + 206 Protein_58 hypothetical protein -
MOO21_RS22910 (MOO21_22905) 53851..57366 - 3516 WP_104769191.1 autotransporter outer membrane beta-barrel domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid mph(A) / aph(6)-Id / aph(3'')-Ib / sul2 / tet(A) / blaTEM-1B - 1..140492 140492


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11116.17 Da        Isoelectric Point: 10.5833

>T252179 WP_000222771.1 NZ_CP101514:52704-52991 [Escherichia coli]
MTYTVKFRDDALKEWLRLDKTIQQQFAKKLKKCSENPHIASAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSNVYHLASERMK

Download         Length: 288 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9171.39 Da        Isoelectric Point: 4.0927

>AT252179 WP_001139206.1 NZ_CP101514:52456-52707 [Escherichia coli]
MPSIILSDTSASVSELKKNPMATVSAGEGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSSQPLHDVDLD
SYL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K4CX11

Antitoxin

Source ID Structure
AlphaFold DB T1PXV2

References