Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3455057..3455675 Replicon chromosome
Accession NZ_CP101513
Organism Escherichia coli strain HH194M

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag MOO21_RS16795 Protein ID WP_001291435.1
Coordinates 3455457..3455675 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag MOO21_RS16790 Protein ID WP_000344800.1
Coordinates 3455057..3455431 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOO21_RS16780 (3450146) 3450146..3451339 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
MOO21_RS16785 (3451362) 3451362..3454511 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
MOO21_RS16790 (3455057) 3455057..3455431 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
MOO21_RS16795 (3455457) 3455457..3455675 + 219 WP_001291435.1 HHA domain-containing protein Toxin
MOO21_RS16800 (3455847) 3455847..3456398 + 552 WP_000102564.1 maltose O-acetyltransferase -
MOO21_RS16805 (3456514) 3456514..3456984 + 471 WP_053878158.1 YlaC family protein -
MOO21_RS16810 (3457148) 3457148..3458698 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
MOO21_RS16815 (3458740) 3458740..3459093 - 354 WP_000878140.1 DUF1428 domain-containing protein -
MOO21_RS16825 (3459472) 3459472..3459783 + 312 WP_000409911.1 MGMT family protein -
MOO21_RS16830 (3459814) 3459814..3460386 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T252176 WP_001291435.1 NZ_CP101513:3455457-3455675 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT252176 WP_000344800.1 NZ_CP101513:3455057-3455431 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References