252175

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2436127..2436765 Replicon chromosome
Accession NZ_CP101513
Organism Escherichia coli strain HH194M

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag MOO21_RS11780 Protein ID WP_000813794.1
Coordinates 2436589..2436765 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag MOO21_RS11775 Protein ID WP_001270286.1
Coordinates 2436127..2436543 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOO21_RS11755 (2431279) 2431279..2432220 - 942 WP_001251319.1 ABC transporter permease -
MOO21_RS11760 (2432221) 2432221..2433234 - 1014 WP_247193865.1 ABC transporter ATP-binding protein -
MOO21_RS11765 (2433252) 2433252..2434397 - 1146 WP_000047429.1 ABC transporter substrate-binding protein -
MOO21_RS11770 (2434639) 2434639..2436048 - 1410 WP_000760625.1 PLP-dependent aminotransferase family protein -
MOO21_RS11775 (2436127) 2436127..2436543 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
MOO21_RS11780 (2436589) 2436589..2436765 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
MOO21_RS11785 (2436987) 2436987..2437217 + 231 WP_000494244.1 YncJ family protein -
MOO21_RS11790 (2437309) 2437309..2439270 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
MOO21_RS11795 (2439343) 2439343..2439879 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
MOO21_RS11800 (2439971) 2439971..2441146 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T252175 WP_000813794.1 NZ_CP101513:c2436765-2436589 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT252175 WP_001270286.1 NZ_CP101513:c2436543-2436127 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References