Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 978145..978728 Replicon chromosome
Accession NZ_CP101513
Organism Escherichia coli strain HH194M

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag MOO21_RS04740 Protein ID WP_049253269.1
Coordinates 978393..978728 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A1V2T5M9
Locus tag MOO21_RS04735 Protein ID WP_000581941.1
Coordinates 978145..978393 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOO21_RS04725 (974484) 974484..975785 + 1302 WP_023281448.1 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD -
MOO21_RS04730 (975833) 975833..978067 + 2235 WP_000226815.1 GTP pyrophosphokinase -
MOO21_RS04735 (978145) 978145..978393 + 249 WP_000581941.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MOO21_RS04740 (978393) 978393..978728 + 336 WP_049253269.1 endoribonuclease MazF Toxin
MOO21_RS04745 (978799) 978799..979590 + 792 WP_001071648.1 nucleoside triphosphate pyrophosphohydrolase -
MOO21_RS04750 (979818) 979818..981455 + 1638 WP_000210878.1 CTP synthase (glutamine hydrolyzing) -
MOO21_RS04755 (981543) 981543..982841 + 1299 WP_000036723.1 phosphopyruvate hydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12197.18 Da        Isoelectric Point: 8.7218

>T252167 WP_049253269.1 NZ_CP101513:978393-978728 [Escherichia coli]
MVSRYVPDMGDLIWVDFDPTKGSEQARHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKS
IAWRARGATKKGTVAPEELQLIKAKINVLIG

Download         Length: 336 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9385.76 Da        Isoelectric Point: 4.4665

>AT252167 WP_000581941.1 NZ_CP101513:978145-978393 [Escherichia coli]
MIHSSVKRWGNSPAVRIPTTLMQALNLNIDDEVKIDLVDGKLIIEPVRKEPVFTLAELVNDITPENLHENIDWGEPKDKE
VW

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1V2T5M9

References